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BioMed Research International
Volume 2013 (2013), Article ID 796014, 7 pages
Increased Toll-Like Receptor Signaling Pathways Characterize CD8+ Cells in Rapidly Progressive SIV Infection
1Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
2Department of Pathology, UCSD School of Medicine, AIDS Research Center, La Jolla, CA 92037, USA
3Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
Received 18 May 2012; Accepted 9 November 2012
Academic Editor: Zhengguo Xiao
Copyright © 2013 Maria Cecilia Garibaldi Marcondes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- E. S. Roberts, M. A. Zandonatti, D. D. Watry et al., “Induction of pathogenic sets of genes in macrophages and neurons in neuroAIDS,” American Journal of Pathology, vol. 162, no. 6, pp. 2041–2057, 2003.
- L. J. Madden, M. A. Zandonatti, C. T. Flynn et al., “CD8+ cell depletion amplifies the acute retroviral syndrome,” Journal of NeuroVirology, vol. 10, no. 1, pp. 58–66, 2004.
- S. J. Bissel, G. Wang, A. M. Trichel, M. Murphey-Corb, and C. A. Wiley, “Longitudinal analysis of monocyte/macrophage infection in simian immunodeficiency virus-infected, CD8+ T-cell-depleted macaques that develop lentiviral encephalitis,” American Journal of Pathology, vol. 168, no. 5, pp. 1553–1569, 2006.
- S. V. Westmoreland, E. Halpern, and A. A. Lackner, “Simian immunodeficiency virus encephalitis in rhesus macaques is associated with rapid disease progression,” Journal of NeuroVirology, vol. 4, no. 3, pp. 260–268, 1998.
- S. M. Smith, B. Holland, C. Russo, P. J. Dailey, P. A. Marx, and R. I. Connor, “Retrospective analysis of viral load and SIV antibody responses in rhesus macaques infected with pathogenic SIV: predictive value for disease progression,” AIDS Research and Human Retroviruses, vol. 15, no. 18, pp. 1691–1701, 1999.
- S. I. Staprans, P. J. Dailey, A. Rosenthal et al., “Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection,” Journal of Virology, vol. 73, no. 6, pp. 4829–4839, 1999.
- M. Dykhuizen, J. L. Mitchen, D. C. Montefiori et al., “Determinants of disease in the simian immunodeficiency virus-infected rhesus macaque: characterizing animals with low antibody responses and rapid progression,” Journal of General Virology, vol. 79, part 10, pp. 2461–2467, 1998.
- L. J. Picker, S. I. Hagen, R. Lum et al., “Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection,” Journal of Experimental Medicine, vol. 200, no. 10, pp. 1299–1314, 2004.
- A. Okoye, M. Meier-Schellersheim, J. M. Brenchley et al., “Progressive CD4+ central-memory T cell decline results in CD4+ effector-memory insufficiency and overt disease in chronic SIV infection,” Journal of Experimental Medicine, vol. 204, no. 9, pp. 2171–2185, 2007.
- M. C. G. Marcondes, S. Sopper, U. Sauermann et al., “CD4 deficits and disease course acceleration can be driven by a collapse of the CD8 response in rhesus macaques infected with simian immunodeficiency virus,” AIDS, vol. 22, no. 12, pp. 1441–1452, 2008.
- D. T. Evans, D. H. O'Connor, P. Jing et al., “Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef,” Nature Medicine, vol. 5, no. 11, pp. 1270–1276, 1999.
- V. M. Hirsch, S. Santra, S. Goldstein et al., “Immune failure in the absence of profound CD4+ T-lymphocyte depletion in simian immunodeficiency virus-infected rapid progressor macaques,” Journal of Virology, vol. 78, no. 1, pp. 275–284, 2004.
- D. T. Evans, P. Jing, T. M. Allen et al., “Definition of five new simian immunodeficiency virus cytotoxic t-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression,” Journal of Virology, vol. 74, no. 16, pp. 7400–7410, 2000.
- R. A. Koup, J. T. Safrit, Y. Cao et al., “Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome,” Journal of Virology, vol. 68, no. 7, pp. 4650–4655, 1994.
- C. M. Hay, D. J. Ruhl, N. O. Basgoz et al., “Lack of viral escape and defective in vivo activation of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes in rapidly progressive infection,” Journal of Virology, vol. 73, no. 7, pp. 5509–5519, 1999.
- S. A. Islam, C. M. Hay, K. E. Hartman et al., “Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression,” Journal of Virology, vol. 75, no. 10, pp. 4907–4911, 2001.
- M. C. G. Marcondes, T. H. Burdo, S. Sopper et al., “Enrichment and persistence of virus-specific CTL in the brain of simian immunodeficiency virus-infected monkeys is associated with a unique cytokine environment,” Journal of Immunology, vol. 178, no. 9, pp. 5812–5819, 2007.
- M. C. G. Marcondes, C. M. S. Lanigan, T. H. Burdo, D. D. Watry, and H. S. Fox, “Increased expression of monocyte CD44v6 correlates with the development of encephalitis in rhesus macaques infected with simian immunodeficiency virus,” Journal of Infectious Diseases, vol. 197, no. 11, pp. 1567–1576, 2008.
- M. C. G. Marcondes, E. M. E. Burudi, S. Huitron-Resendiz et al., “Highly activated CD8+ T cells in the brain correlate with early central nervous system dysfunction in simian immunodeficiency virus infection,” Journal of Immunology, vol. 167, no. 9, pp. 5429–5438, 2001.
- A. Sakhdari, S. Mujib, B. Vali et al., “Tim-3 negatively regulates cytotoxicity in exhausted CD8 + T cells in HIV infection,” PLoS One, vol. 7, no. 7, Article ID 40146, 2012.
- N. Funderburg, A. A. Luciano, W. Jiang, B. Rodriguez, S. F. Sieg, and M. M. Lederman, “Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis,” PLoS One, vol. 3, no. 4, Article ID e1915, 2008.
- A. O. Aliprantis, R. B. Yang, D. S. Weiss, P. Godowski, and A. Zychlinsky, “The apoptotic signaling pathway activated by Toll-like receptor-2,” EMBO Journal, vol. 19, no. 13, pp. 3325–3336, 2000.
- M. Raisova, A. M. Hossini, J. Eberle et al., “The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis,” Journal of Investigative Dermatology, vol. 117, no. 2, pp. 333–340, 2001.
- A. Meier, G. Alter, N. Frahm et al., “MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded toll-like receptor ligands,” Journal of Virology, vol. 81, no. 15, pp. 8180–8191, 2007.
- G. Mancuso, M. Gambuzza, A. Midiri et al., “Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells,” Nature Immunology, vol. 10, no. 6, pp. 587–594, 2009.
- A. S. Beignon, K. McKenna, M. Skoberne et al., “Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions,” Journal of Clinical Investigation, vol. 115, no. 11, pp. 3265–3275, 2005.
- C. L. Ahonen, C. L. Doxsee, S. M. McGurran et al., “Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN,” Journal of Experimental Medicine, vol. 199, no. 6, pp. 775–784, 2004.
- B. Brichacek, C. Vanpouille, Y. Kiselyeva et al., “Contrasting roles for TLR ligands in HIV-1 pathogenesis,” PLoS One, vol. 5, no. 9, Article ID e12831, pp. 1–12, 2010.
- U. Hasan, C. Chaffois, C. Gaillard et al., “Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88,” Journal of Immunology, vol. 174, no. 5, pp. 2942–2950, 2005.
- A. A. C. Lemckert, J. Goudsmit, and D. H. Barouch, “Challenges in the search for an HIV vaccine,” European Journal of Epidemiology, vol. 19, no. 6, pp. 513–516, 2004.
- M. Tritel, A. M. Stoddard, B. J. Flynn et al., “Prime-boost vaccination with HIV-1 gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses,” Journal of Immunology, vol. 171, no. 5, pp. 2538–2547, 2003.
- U. Wille-Reece, B. J. Flynn, K. Loré et al., “HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 42, pp. 15190–15194, 2005.
- U. Wille-Reece, B. J. Flynn, K. Loré et al., “Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates,” Journal of Experimental Medicine, vol. 203, no. 5, pp. 1249–1258, 2006.
- S. Baenziger, M. Heikenwalder, P. Johansen et al., “Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology,” Blood, vol. 113, no. 2, pp. 377–388, 2009.
- J. N. Mandl, A. P. Barry, T. H. Vanderford et al., “Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections,” Nature Medicine, vol. 14, no. 10, pp. 1077–1087, 2008.
- D. Y. Oh, K. Baumann, O. Hamouda et al., “A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression,” AIDS, vol. 23, no. 3, pp. 297–307, 2009.
- E. Chung, S. B. Amrute, K. Abel et al., “Characterization of virus-responsive plasmacytoid dendritic cells in the rhesus macaque,” Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 3, pp. 426–435, 2005.