- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 807863, 12 pages
In Vitro Large Scale Production of Human Mature Red Blood Cells from Hematopoietic Stem Cells by Coculturing with Human Fetal Liver Stromal Cells
Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, 27 Taiping Road, Beijing 100850, China
Received 28 September 2012; Accepted 2 December 2012
Academic Editor: Xuan Jin
Copyright © 2013 Jiafei Xi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- K. Muta, S. B. Krantz, M. C. Bondurant, and A. Wickrema, “Distinct roles of erythropoietin, insulin-like growth factor I, and stem cell factor in the development of erythroid progenitor cells,” Journal of Clinical Investigation, vol. 94, no. 1, pp. 34–43, 1994.
- H. Dolznig, B. Habermann, K. Stangl et al., “Apoptosis protection by the Epo target Bcl-XL allows factor-independent differentiation of primary erythroblasts,” Current Biology, vol. 12, no. 13, pp. 1076–1085, 2002.
- S. I. Miyagawa, M. Kobayashi, N. Konishi, T. Sato, and K. Ueda, “Insulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors,” British Journal of Haematology, vol. 109, no. 3, pp. 555–562, 2000.
- M. Von Lindern, W. Zauner, G. Mellitzer et al., “The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro,” Blood, vol. 94, no. 2, pp. 550–559, 1999.
- H. Dolznig, F. Boulmé, K. Stangl et al., “Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays,” The FASEB Journal, vol. 15, no. 8, pp. 1442–1444, 2001.
- J. N. Barker and J. E. Wagner, “Umbilical-cord blood transplantation for the treatment of cancer,” Nature Reviews Cancer, vol. 3, no. 7, pp. 526–532, 2003.
- J. N. Barker and J. E. Wagner, “Umbilical cord blood transplantation: current state of the art,” Current Opinion in Oncology, vol. 14, no. 2, pp. 160–164, 2002.
- I. Rogers and R. F. Casper, “Stem cells: you can't tell a cell by its cover,” Human Reproduction Update, vol. 9, no. 1, pp. 25–33, 2003.
- H. Wada, T. Suda, Y. Miura, E. Kajii, S. Ikemoto, and Y. Yawata, “Expression of major blood group antigens on human erythroid cells in a two phase liquid culture system,” Blood, vol. 75, no. 2, pp. 505–511, 1990.
- E. Fibach and E. A. Rachmilewitz, “The two-step liquid culture: a novel procedure for studying maturation of human normal and pathological erythroid precursors,” Stem Cells, vol. 11, pp. 36–41, 1993.
- M. S. Scicchitano, D. C. McFarland, L. A. Tierney, P. K. Narayanan, and L. W. Schwartz, “In vitro expansion of human cord blood CD36+ erythroid progenitors: temporal changes in gene and protein expression,” Experimental Hematology, vol. 31, no. 9, pp. 760–769, 2003.
- T. M. A. Neildez-Nguyen, H. Wajcman, M. C. Marden et al., “Human erythroid cells produced ex vivo at large scale differentiate into red blood cells in vivo,” Nature Biotechnology, vol. 20, no. 5, pp. 467–472, 2002.
- M. C. Giarratana, L. Kobari, H. Lapillonne et al., “Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells,” Nature Biotechnology, vol. 23, no. 1, pp. 69–74, 2005.
- S. J. Lu, Q. Feng, J. S. Park et al., “Biologic properties and enucleation of red blood cells from human embryonic stem cells,” Blood, vol. 112, no. 12, pp. 4475–4484, 2008.
- J. Isern, S. T. Fraser, Z. He, and M. H. Baron, “The fetal liver is a niche for maturation of primitive erythroid cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 18, pp. 6662–6667, 2008.
- M. J. Koury, S. T. Sawyer, and S. J. Brandt, “New insights into erythropoiesis,” Current Opinion in Hematology, vol. 9, no. 2, pp. 93–100, 2002.
- J. A. Chasis, “Erythroblastic islands: specialized microenvironmental niches for erythropoiesis,” Current Opinion in Hematology, vol. 13, no. 3, pp. 137–141, 2006.
- B. T. Spike, B. C. Dibling, and K. F. Macleod, “Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse,” Blood, vol. 110, no. 6, pp. 2173–2181, 2007.
- B. T. Spike and K. F. Macleod, “Effects of hypoxia on heterotypic macrophage interactions,” Cell Cycle, vol. 6, no. 21, pp. 2620–2624, 2007.
- C. Leberbauer, F. Boulmé, G. Unfried, J. Huber, H. Beug, and E. W. Müllner, “Different steroids co-regulate long-term expansion versus terminal differentiation in primary human erythroid progenitors,” Blood, vol. 105, no. 1, pp. 85–94, 2005.
- E. van den Akker, T. J. Satchwell, S. Pellegrin, G. Daniels, and A. M. Toye, “The majority of the in vitro erythroid expansion potential resides in CD34- cells, outweighing the contribution of CD34+ cells and significantly increasing the erythroblast yield from peripheral blood samples,” Haematologica, vol. 95, no. 9, pp. 1594–1598, 2010.
- M. Kennedy, H. Beug, E. F. Wagner, and G. Keller, “Factor-dependent erythroid cell lines derived from mice transplanted with hematopoietic cells expressing the v-src oncogene,” Blood, vol. 79, no. 1, pp. 180–190, 1992.
- J. F. Xi, Y. F. Wang, P. Zhang et al., “Establishment of fetal liver stroma cell lines which stably express basic fibroblast growth factor by lentiviral system,” Progress in Biochemistry and Biophysics, vol. 34, no. 2, pp. 207–214, 2007.
- C. Cerdan, A. Rouleau, and M. Bhatia, “VEGF-A165 augments erythropoietic development from human embryonic stem cells,” Blood, vol. 103, no. 7, pp. 2504–2512, 2004.
- B. Panzenböck, P. Bartunek, M. Y. Mapara, and M. Zenke, “Growth and differentiation of human stem cell factor/erythropoietin- dependent erythroid progenitor cells in vitro,” Blood, vol. 92, no. 10, pp. 3658–3668, 1998.
- R. Sutherland, D. Delia, C. Schneider, R. Newman, J. Kemshead, and M. Greaves, “Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin,” Proceedings of the National Academy of Sciences of the United States of America, vol. 78, no. 7, pp. 4515–4519, 1981.
- U. Wojda, P. Noel, and J. L. Miller, “Fetal and adult hemoglobin production during adult erythropoiesis: coordinate expression correlates with cell proliferation,” Blood, vol. 99, no. 8, pp. 3005–3013, 2002.
- V. Di Giacomo, A. Matteucci, E. Stellacci et al., “Expression of signal transduction proteins during the differentiation of primary human erythroblasts,” Journal of Cellular Physiology, vol. 202, no. 3, pp. 831–838, 2005.
- G. Migliaccio, R. Di Pietro, V. Di Giacomo et al., “In vitro mass production of human erythroid cells from the blood of normal donors and of thalassemic patients,” Blood Cells, Molecules, and Diseases, vol. 28, no. 2, pp. 169–180, 2002.
- J. H. Kie, Y. J. Jung, S. Y. Woo et al., “Ultrastructural and phenotypic analysis of in vitro erythropoiesis from human cord blood CD34+ cells,” Annals of Hematology, vol. 82, no. 5, pp. 278–283, 2003.
- J. Wineman, K. Moore, I. Lemischka, and C. Müller-Sieburg, “Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells,” Blood, vol. 87, no. 10, pp. 4082–4090, 1996.
- J. Domen and I. L. Weissman, “Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate,” Molecular Medicine Today, vol. 5, no. 5, pp. 201–208, 1999.
- P. Malik, T. C. Fisher, L. L. W. Barsky et al., “An in vitro model of human red blood cell production from hematopoietic progenitor cells,” Blood, vol. 91, no. 8, pp. 2664–2671, 1998.
- M. Hanspal and J. S. Hanspal, “The association of erythroblasts with macrophages promotes erythroid proliferation and maturation: a 30-kD heparin-binding protein is involved in this contact,” Blood, vol. 84, no. 10, pp. 3494–3504, 1994.
- L. Douay and G. Andreu, “Ex vivo production of human red blood cells from hematopoietic stem cells: what is the future in transfusion?” Transfusion Medicine Reviews, vol. 21, no. 2, pp. 91–100, 2007.
- F. Ma, D. Wang, S. Hanada et al., “Novel method for efficient production of multipotential hematopoietic progenitors from human embryonic stem cells,” International Journal of Hematology, vol. 85, no. 5, pp. 371–379, 2007.
- F. Ma, Y. Ebihara, K. Umeda et al., “Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 35, pp. 13087–13092, 2008.
- K. Y. Lee, B. S. P. Fong, K. S. Tsang et al., “Fetal stromal niches enhance human embryonic stem cell-derived hematopoietic differentiation and globin switch,” Stem Cells and Development, vol. 20, no. 1, pp. 31–38, 2011.
- S. Chou and H. F. Lodish, “Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 17, pp. 7799–7804, 2010.
- J. Zhu and S. G. Emerson, “Hematopoietic cytokines, transcription factors and lineage commitment,” Oncogene, vol. 21, no. 21, pp. 3295–3313, 2002.
- A. B. Cantor and S. H. Orkin, “Transcriptional regulation of erythropoiesis: an affair involving multiple partners,” Oncogene, vol. 21, no. 21, pp. 3368–3376, 2002.
- K. McGrath and J. Palis, “Ontogeny of erythropoiesis in the mammalian embryo,” Current Topics in Developmental Biology, vol. 82, pp. 1–22, 2008.
- J. Palis, “Ontogeny of erythropoiesis,” Current Opinion in Hematology, vol. 15, no. 3, pp. 155–161, 2008.
- J. Borg, P. Papadopoulos, M. Georgitsi et al., “Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin,” Nature genetics, vol. 42, no. 9, pp. 801–805, 2010.