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BioMed Research International
Volume 2013 (2013), Article ID 913179, 8 pages
http://dx.doi.org/10.1155/2013/913179
Research Article

Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells

1Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA
2Institute of Disease Control and Prevention, Chinese Academy of Military Medical Sciences, Beijing 100071, China
3Science Applications International Corporation-Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, USA
4Dermatology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA

Received 25 February 2013; Accepted 3 May 2013

Academic Editor: Tiziano Verri

Copyright © 2013 Jianjun Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prostate stem cells are thought to be responsible for generation of all prostate epithelial cells and for tissue maintenance. The lineage relationship between basal and luminal cells in the prostate is not well clarified. We developed a mouse model to trace cell fate and a mouse model with a slowly cycling cell label to provide insight into this question. The results obtained indicate that putative mouse prostate stem cells are likely to reside in the basal layer.