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BioMed Research International
Volume 2014, Article ID 103906, 12 pages
Research Article

Protective Effects of Testosterone on Presynaptic Terminals against Oligomeric -Amyloid Peptide in Primary Culture of Hippocampal Neurons

1Laboratory of Neurodegenerative Diseases, Department of Anatomy, LKS Faculty of Medicine, Room L1-49, 21 Sassoon Road, Pokfulam, Hong Kong
2State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau
3Institute of Chinese Medicinal Science, University of Macau, Macau
4Department of Psychiatry, LKS Faculty of Medicine, Hong Kong
5Department of Ophthalmology, LKS Faculty of Medicine, Hong Kong
6Shenzhen Centre for Disease Control and Prevention, Shenzhen, China
7Division of Geriatric, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, SAR, Hong Kong
8Research Centre of Heart, Brain, Hormone and Healthy Aging, LKS Faculty of Medicine, Hong Kong
9State Key Laboratory of Brain and Cognitive Sciences, Hong Kong

Received 15 March 2014; Revised 14 May 2014; Accepted 14 May 2014; Published 18 June 2014

Academic Editor: Jin-Tai Yu

Copyright © 2014 Chi-Fai Lau et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Oligomeric Aβ-induced did not reduce the expression of PSD-95 in primary hippocampal neurons. Primary hippocampal neurons were exposed to 5 μM oligomeric Aβ for 24 h. Neurons were stained with PSD-95 antibody. (A) Control, (B) 5 μM Aβ for 24 h. Representative photos were captured by Carl Zeiss LSM-510Meta/Axiocam inverted confocal microscope.

  1. Supplementary Figure