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BioMed Research International
Volume 2014 (2014), Article ID 136419, 14 pages
Review Article

Comparative Evaluation of Recombinant Protein Production in Different Biofactories: The Green Perspective

Department of Biotechnology, University of Verona, 37134 Verona, Italy

Received 6 December 2013; Accepted 10 February 2014; Published 12 March 2014

Academic Editor: Luca Santi

Copyright © 2014 Matilde Merlin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In recent years, the production of recombinant pharmaceutical proteins in heterologous systems has increased significantly. Most applications involve complex proteins and glycoproteins that are difficult to produce, thus promoting the development and improvement of a wide range of production platforms. No individual system is optimal for the production of all recombinant proteins, so the diversity of platforms based on plants offers a significant advantage. Here, we discuss the production of four recombinant pharmaceutical proteins using different platforms, highlighting from these examples the unique advantages of plant-based systems over traditional fermenter-based expression platforms.