BioMed Research International

Plant-Made Biologics


Publishing date
27 Jun 2014
Status
Published
Submission deadline
07 Feb 2014

1Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA

2Pharmaceutical Biotechnology, Department of Science and Technology for Agriculture, Forestry, Nature and Energy (DAFNE), University of Tuscia, Via San Camillo de Lellis snc, 01100 Viterbo, Italy

3Department of Biological Systems Engineering, Virginia Tech, Blacksburg, VA 24061, USA


Plant-Made Biologics

Description

The increasing world demand for human biologics cannot be met by current production platforms primarily based on mammalian cell culture due to prohibitive cost and limited scalability. Recent progress in expression vector development, downstream processing, and glycoengineering has established plants as a superior alternative for biologic production. Plants offer not only the traditional advantages of proper eukaryotic protein modification, low cost, high scalability, and increased safety, but also allow the production of biologics at unprecedented speed to control potential pandemics with specific glycoforms for better efficacy (biobetters). The recent approval of the first plant-made biologic (PMB) by the FDA for treating Gaucher’s disease heralds a new era for PMBs and sparks new innovations in this field.

This special issue invites original research and review articles that report the recent developments and application of PMBs. Potential topics include, but are not limited to:

  • Expression vector and platform development
  • Plant production host development
  • Novel biologic products (e.g., biobetters and biosimilars)
  • Glycoengineering and posttranslational modification
  • Downstream processing and purification
  • Analytical method development
  • Product functional characterization
  • Clinical testing
  • cGMP and commercialization
  • Regulatory compliance and intellectual property
  • Economic impact and evaluation

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biotechnology/pmb/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 418064
  • - Editorial

Plant-Made Biologics

Qiang Chen | Luca Santi | Chenming Zhang
  • Special Issue
  • - Volume 2014
  • - Article ID 256135
  • - Research Article

Manufacturing Economics of Plant-Made Biologics: Case Studies in Therapeutic and Industrial Enzymes

Daniel Tusé | Tiffany Tu | Karen A. McDonald
  • Special Issue
  • - Volume 2014
  • - Article ID 483596
  • - Research Article

Quantitative Evaluation of E1 Endoglucanase Recovery from Tobacco Leaves Using the Vacuum Infiltration-Centrifugation Method

Nathaniel J. Kingsbury | Karen A. McDonald
  • Special Issue
  • - Volume 2014
  • - Article ID 249519
  • - Review Article

N-Glycosylation Modification of Plant-Derived Virus-Like Particles: An Application in Vaccines

Hyun-Soon Kim | Jae-Heung Jeon | ... | Kisung Ko
  • Special Issue
  • - Volume 2014
  • - Article ID 807539
  • - Research Article

Norovirus Narita 104 Virus-Like Particles Expressed in Nicotiana benthamiana Induce Serum and Mucosal Immune Responses

Lolita George Mathew | Melissa M. Herbst-Kralovetz | Hugh S. Mason
  • Special Issue
  • - Volume 2014
  • - Article ID 340804
  • - Research Article

Soybean Seeds: A Practical Host for the Production of Functional Subunit Vaccines

Laura C. Hudson | Renu Garg | ... | Kenneth J. Piller
  • Special Issue
  • - Volume 2014
  • - Article ID 952865
  • - Research Article

A Plant-Produced Antigen Elicits Potent Immune Responses against West Nile Virus in Mice

Junyun He | Li Peng | ... | Qiang Chen
  • Special Issue
  • - Volume 2014
  • - Article ID 785382
  • - Review Article

Plant Virus Expression Vector Development: New Perspectives

Kathleen Hefferon
  • Special Issue
  • - Volume 2014
  • - Article ID 136419
  • - Review Article

Comparative Evaluation of Recombinant Protein Production in Different Biofactories: The Green Perspective

Matilde Merlin | Elisa Gecchele | ... | Linda Avesani
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision77 days
Acceptance to publication52 days
CiteScore2.410
Impact Factor2.197
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