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BioMed Research International
Volume 2014, Article ID 159632, 5 pages
http://dx.doi.org/10.1155/2014/159632
Research Article

Serum Soluble TACI, a BLyS Receptor, Is a Powerful Prognostic Marker of Outcome in Chronic Lymphocytic Leukemia

1Hematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, Greece
2Hematology Clinic of Athens’ Medical Center, Andersen 1, Psychiko, 11525 Athens, Greece

Received 17 April 2014; Accepted 20 July 2014; Published 6 August 2014

Academic Editor: Kazuyuki Shimizu

Copyright © 2014 Marie-Christine Kyrtsonis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

BLyS is involved in CLL biology and its low soluble serum levels related to a shorter time to first treatment (TFT). TACI is a BLyS receptor and can be shed from cells’ surface and circulate in soluble form (sTACI). We investigated the impact of serum BLyS and sTACI levels at diagnosis in CLL patients and their relationship with disease parameters and patients’ outcome. Serum BLyS was determined in 73 patients, while sTACI in 60. Frozen sera drawn at diagnosis were tested by ELISA. sTACI concentrations correlated with BLyS (), b2-microglobulin (), anemia (), thrombocytopenia (), Binet stage (), and free light chains ratio (). Soluble BLyS levels below median and sTACI values above median were related to shorter TFT ( and 0.007). During a ten-year followup, sTACI levels, but not BLyS, correlated with survival (). In conclusion, we confirmed the prognostic significance of soluble BLyS levels with regard to TFT in CLL patients, and, more importantly, we showed for the first time that sTACI is a powerful prognostic marker, related to parameters of disease activity and staging and, more importantly, to TFT and OS.