Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents
Figure 2
Screening of guanidinium derivatives for vasodilatation. Guanidinium derivatives (10 μmol/L), agmatine, amiloride, metformin, allantoin, canavanine, and aminoguanidine induced relaxation in isolated aortic rings precontracted with 1 μmol/L phenylephrine (a) or 50 mmol/L KCl (b). Data represent the mean ± SEM of eight animals in each column. All values are presented as mean ± SEM (). * as compared to the precontracted value.
