Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents

Figure 5

Vasodilatation in isolated aortic ring after cotreatment with agmatine and amiloride. Vasodilatation was enhanced by cotreatment with agmatine (10 μmol/L) and amiloride (10 μmol/L) in isolated aortic rings precontracted with 1 μmol/L phenylephrine (a) or 50 mmol/L KCl (b). All values are shown as mean ± SEM (𝑛=8). **𝑃<0.01 and ***𝑃<0.001 as compared to the precontracted value.

(a)

(b)