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BioMed Research International
Volume 2014, Article ID 193095, 16 pages
Review Article

Nitric Oxide, Oxidative Stress, and Interplay in Diabetic Endothelial Dysfunction

1Vascular Pathology Laboratory, Istituto Dermopatico dell’Immacolata-IRCCS, 00167 Rome, Italy
2Molecular Cardiology Laboratory, Policlinico San Donato-IRCCS, San Donato Milanese, 20097 Milan, Italy
3Division of Cardiovascular Epigenetics, Department of Cardiology, Internal Medicine Clinic III, Goethe University, 60590 Frankfurt am Main, Germany

Received 18 November 2013; Accepted 12 January 2014; Published 5 March 2014

Academic Editor: Silvia M. Arribas

Copyright © 2014 Alessandra Magenta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Increased oxidative stress and reduced nitric oxide (NO) bioavailability play a causal role in endothelial cell dysfunction occurring in the vasculature of diabetic patients. In this review, we summarized the molecular mechanisms underpinning diabetic endothelial and vascular dysfunction. In particular, we focused our attention on the complex interplay existing among NO, reactive oxygen species (ROS), and one crucial regulator of intracellular ROS production, protein.