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BioMed Research International
Volume 2014, Article ID 196034, 7 pages
http://dx.doi.org/10.1155/2014/196034
Research Article

Syn-Lethality: An Integrative Knowledge Base of Synthetic Lethality towards Discovery of Selective Anticancer Therapies

1Bioinformatics Research Centre (BIRC), School of Computer Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798
2Institute for Infocomm Research (I2R), 1 Fusionopolis Way, Singapore 138632
3Genome Institute of Singapore (GIS), Biopolis, Singapore 138672

Received 17 November 2013; Accepted 11 March 2014; Published 22 April 2014

Academic Editor: FangXiang Wu

Copyright © 2014 Xue-juan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Boyle and B. E. Levin, World Cancer Report, IARC Press, 2008.
  2. W. G. Kaelin, “Synthetic lethality: a framework for the development of wiser cancer therapeutics,” Genome Medicine, vol. 1, no. 10, article 99, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. W. G. Kaelin Jr., “The concept of synthetic lethality in the context of anticancer therapy,” Nature Reviews Cancer, vol. 5, no. 9, pp. 689–698, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. L. H. Hartwell, P. Szankasi, C. J. Roberts, A. W. Murray, and S. H. Friend, “Integrating genetic approaches into the discovery of anticancer drugs,” Science, vol. 278, no. 5340, pp. 1064–1068, 1997. View at Publisher · View at Google Scholar · View at Scopus
  5. M. A. Heiskanen and T. Aittokallio, “Mining high-throughput screens for cancer drug targetslessons from yeast chemical-genomic profiling and synthetic lethality,” WIREs Data Mining Knowl Discovery, vol. 2, no. 3, pp. 263–272, 2012. View at Google Scholar
  6. M. Wu, X. J. Li, F. Zhang, X. L. Li, C. K. Kwoh, and J. Zheng, Meta-Analysis of Genomic and Proteomic Features To Predict Synthetic Lethality of Yeast and Human Cancer, ACM-BCB, 2013.
  7. K. W. Y. Yuen, C. D. Warren, O. Chen, T. Kwok, P. Hieter, and F. A. Spencer, “Systematic genome instability screens in yeast and their potential relevance to cancer,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 10, pp. 3925–3930, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Conde-Pueyo, A. Munteanu, R. V. Solé, and C. Rodríguez-Caso, “Human synthetic lethal inference as potential anti-cancer target gene detection,” BMC Systems Biology, vol. 3, article 116, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Chatr-Aryamontri, B. J. Breitkreutz, S. Heinicke et al., “The biogrid interaction database: 2013 update,” Nucleic Acids Research, vol. 41, pp. 816–823, 2013. View at Publisher · View at Google Scholar
  10. J. Luo, M. J. Emanuele, D. Li et al., “A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the ras oncogene,” Cell, vol. 137, no. 5, pp. 835–848, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Morandell and M. B. Yaffe, “Exploiting synthetic lethal interactions between dna damage signaling, checkpoint control, and p53 for targeted cancer therapy,” Progress in Molecular Biology and Translational Science, vol. 110, pp. 289–314, 2012. View at Publisher · View at Google Scholar
  12. Y. Wang, I. H. Engels, D. A. Knee, M. Nasoff, Q. L. Deveraux, and K. C. Quon, “Synthetic lethal targeting of MYC by activation of the DR5 death receptor pathway,” Cancer Cell, vol. 5, no. 5, pp. 501–512, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Le Meur and R. Gentleman, “Modeling synthetic lethality,” Genome Biology, vol. 9, no. 9, article 135, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Nowsheen, T. Cooper, J. A. Stanley, and E. S. Yang, “Synthetic lethal interactions between egfr and parp inhibition in human triple negative breast cancer cells,” PLoS ONE, vol. 7, no. 10, Article ID e46614, 2012. View at Publisher · View at Google Scholar
  15. D. A. Barbie, P. Tamayo, J. S. Boehm et al., “Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1,” Nature, vol. 462, no. 7269, pp. 108–112, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Dong, A. Li, J. Wang, J. D. Weber, and L. S. Michel, “Synthetic lethality through combined notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer,” Cancer Research, vol. 70, no. 13, pp. 5465–5474, 2010. View at Publisher · View at Google Scholar · View at Scopus