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BioMed Research International
Volume 2014, Article ID 196837, 10 pages
Research Article

Reliable Assessment and Quantification of the Fluorescence-Labeled Antisense Oligonucleotides In Vivo

Department of Biomedical Engineering, National Cerebral and Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan

Received 25 February 2014; Revised 22 April 2014; Accepted 22 April 2014; Published 25 May 2014

Academic Editor: Pradeep Kumar

Copyright © 2014 Maria Chiara Munisso and Tetsuji Yamaoka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Gel permeation chromatography (GPC) results of the macro-initiators and co-polymers are reported in S.(1). 1H NMR measurements of MBP (S.(2)A), pGAMA (S.(2)B), DMAEMA (S.(2)C), pGa4D47 (S.(3)) and pGu4D40(S.(4)) are reported in S. (2), (3), and (4) respectively. In S.(5) are reported the tabulate of the fluorescence data of the Standard curve by (A) MAESTRO and (B) Varioskan. The curves are plotted in Figure: 5.

  1. Supplementary Material