BioMed Research International

Advances in Gene Delivery Systems


Status
Published

Lead Editor

1Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, Bandarsindri, N.H. 8, Tehsil Kishangarh, District Ajmer, Rajasthan, 305801, India

2Genomics and Nanotoxicology, Laboratory Mechanistic Studies Division, Health Canada, Ottawa, ON, Canada

3Department of Electro and Biophysics (Plasma Bioscience Research Centre), Kwangwoon University, Wolgye-Dong, Nowon-gu, Seoul 139-701, Republic of Korea

4Nucleic Acids Research Laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi 110007, India


Advances in Gene Delivery Systems

Description

Gene therapy can be defined as incorporation of genetic material (i.e., DNA or RNA) in the cellular gene regulation system, either to correct the expression of a malfunctioning gene or to modulate the cellular functions through expression of the newly incorporated gene. However, the effective functioning of genetic material is hampered by rapid degradation by the nucleases present in the in vitro and in vivo milieu. To circumvent this issue and achieve efficient and targeted gene delivery, numerous vectors have been developed, broadly categorized as viral and nonviral vectors. The viral vectors owing to their naturally evolved transduction properties were initially proposed as potential carriers due to site specificity, but their large clinical application is hindered because of immunogenicity and pathogenicity. Later, a wide variety of nonviral vectors were engineered from polycationic lipids, polypeptides, histones, and other chromosomal proteins, hydrogel polymers, calcium phosphate nanoparticles, metallic nanoparticles, and cationic polymers.

We invite researchers to submit original research as well as review articles that will stimulate the quest towards development of safe, efficient, and target-oriented delivery vectors for gene therapy. We are interested in articles that explore various dimensions of gene delivery (i.e., right from preparation, characterization of novel vectors to their in vitro and in vivo studies in animal models or humans). Potential topics include, but are not limited to:

  • Exploring novel strategies for preparation of gene delivery vectors
  • Advances in tools and techniques for characterization of gene delivery vectors
  • In vitro studies dealing with efficient and target directed gene delivery via vectors
  • Explore the cytotoxicity potential of novel vectors employed for gene delivery
  • Chemical and biochemical manipulations of vectors to achieve disease specific gene delivery such as cancer

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biomaterials/agds/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 610342
  • - Editorial

Advances in Gene Delivery Systems

Surendra Nimesh | Sabina Halappanavar | ... | Pradeep Kumar
  • Special Issue
  • - Volume 2015
  • - Article ID 834079
  • - Review Article

Delivery of Nucleic Acids and Nanomaterials by Cell-Penetrating Peptides: Opportunities and Challenges

Yue-Wern Huang | Han-Jung Lee | ... | Robert S. Aronstam
  • Special Issue
  • - Volume 2014
  • - Article ID 934605
  • - Review Article

Recent Trends of Polymer Mediated Liposomal Gene Delivery System

Shyamal Kumar Kundu | Ashish Ranjan Sharma | ... | Chiranjib Chakraborty
  • Special Issue
  • - Volume 2014
  • - Article ID 646787
  • - Research Article

Gene Delivery Potential of Biofunctional Carbonate Apatite Nanoparticles in Lungs

Suleiman Yusuf Alhaji | Ezharul Houque Chowdhury | ... | Syahril Abdullah
  • Special Issue
  • - Volume 2014
  • - Article ID 327950
  • - Review Article

Next Generation Delivery System for Proteins and Genes of Therapeutic Purpose: Why and How?

Ashish Ranjan Sharma | Shyamal Kumar Kundu | ... | Chiranjib Chakraborty
  • Special Issue
  • - Volume 2014
  • - Article ID 196837
  • - Research Article

Reliable Assessment and Quantification of the Fluorescence-Labeled Antisense Oligonucleotides In Vivo

Maria Chiara Munisso | Tetsuji Yamaoka
  • Special Issue
  • - Volume 2014
  • - Article ID 459736
  • - Research Article

Synthesis and Evaluation of Tetramethylguanidinium-Polyethylenimine Polymers as Efficient Gene Delivery Vectors

Manohar Mahato | Santosh Yadav | ... | Ashwani Kumar Sharma
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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