Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 204604, 6 pages
Research Article

ATP during Early Bladder Stretch Is Important for Urgency in Detrusor Overactivity Patients

1Department of Urogynaecology, St George Hospital, University of New South Wales, Level 1, W.R. Pitney Building, Sydney, NSW 2217, Australia
2Graduate School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia
3Faculty of Health Sciences & Medicine, Bond University, Gold Coast, QLD 4229, Australia
4Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia

Received 28 February 2014; Revised 28 April 2014; Accepted 15 May 2014; Published 27 May 2014

Academic Editor: Michael Winder

Copyright © 2014 Y. Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


ATP is an important mediator of urgency in women with detrusor overactivity (DO). In order to understand how different degrees of bladder stretch elicited ATP release in DO patients compared with controls, sequential aliquots were collected during cystometry and ATP release was measured at each degree of bladder filling, in female patients with DO and controls. In both DO and control groups, ATP release was induced during bladder filling, suggesting that stretch stimulated further ATP release. However, the luminal ATP concentrations were already high at early filling stage (200 mL), which was even greater than those at the later filling stages (400 mL and maximum cystometric capacity, MCC), indicating that a substantial ATP release has been induced during early filling (200 mL) in both DO and controls. In DO, ATP release at 200 mL was significantly higher in those with low first desire to void (FDV) (≤200 mL) than in those with higher FDV (>200 mL); this may suggest that ATP release at early stretch may play an important role in urgency (early sensation) in DO. ATP concentrations remained unchanged after voiding, suggesting that voiding did not further induce ATP release into intraluminal fluid.