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BioMed Research International
Volume 2014 (2014), Article ID 240642, 8 pages
http://dx.doi.org/10.1155/2014/240642
Review Article

Animal Models in Studies of Cardiotoxicity Side Effects from Antiblastic Drugs in Patients and Occupational Exposed Workers

1Department of Experimental Medicine, Section of Hygiene, Occupational Medicine and Forensic Medicine, Area of Occupational Medicine, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy
2National Institute for the Study and Treatment of Cancer, Foundation “G. Pascale”, Via Mariano Semmola, 80131 Napoli, Italy
3Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy
4Department of Radiology, Oncology and Pathological Anatomy Sciences, University of Rome, “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy
5Spencer-Lorillard Foundation, University of Rome, “La Sapienza”, Piazzale Aldo Moro 5, 00185 Rome, Italy
6Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Building Suite 431, 1900 North 12th Street, Philadelphia, PA 19122, USA

Received 31 July 2013; Revised 29 October 2013; Accepted 7 November 2013; Published 19 February 2014

Academic Editor: Monica Fedele

Copyright © 2014 Monica Lamberti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cardiotoxicity is an important side effect of cytotoxic drugs and may be a risk factor of long-term morbidity for both patients during therapy and also for staff exposed during the phases of manipulation of antiblastic drugs. The mechanism of cardiotoxicity studied in vitro and in vivo essentially concerns the formation of free radicals leading to oxidative stress, with apoptosis of cardiac cells or immunologic reactions, but other mechanisms may play a role in antiblastic-induced cardiotoxicity. Actually, some new cytotoxic drugs like trastuzumab and cyclopentenyl cytosine show cardiotoxic effects. In this report we discuss the different mechanisms of cardiotoxicity induced by antiblastic drugs assessed using animal models.