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BioMed Research International
Volume 2014, Article ID 305239, 11 pages
http://dx.doi.org/10.1155/2014/305239
Research Article

Gene Expression Changes Induced by Trypanosoma cruzi Shed Microvesicles in Mammalian Host Cells: Relevance of tRNA-Derived Halves

1Functional Genomics Unit, Institut Pasteur de Montevideo, Mataojo 2020, 11400 Montevideo, Uruguay
2Laboratório de Biologia Celular e Ultraestrutura, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil
3Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Avenue Carlos Chagas Filho 373, 21941-902 Rio de Janeiro, RJ, Brazil
4Department of Medicine, Faculty of Medicine, Avenida Italia s/n, 11600 Montevideo, Uruguay

Received 5 December 2013; Accepted 1 March 2014; Published 9 April 2014

Academic Editor: Marlene Benchimol

Copyright © 2014 Maria R. Garcia-Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Table S1: List of oligoribonucleotides used for transfections, FISH and RT-PCR

Table S2: A complete list of HeLa genes modified by extracellular vesicles at different time points

Supplementary Figure 1: Bioinformatic prediction for target sites for tsRNA Thr in the mRNAs studied showing the binding sites and the corresponding free energy values.

  1. Supplementary Table 1
  2. Supplementary Table 2
  3. Supplementary Figure 1