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BioMed Research International
Volume 2014, Article ID 309507, 7 pages
http://dx.doi.org/10.1155/2014/309507
Research Article

Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment

1Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy
2Gerontology and Geriatric Research Laboratory, IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Viale Cappuccini 1, 71013 Foggia, Italy
3Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
4Department of Life Sciences and Biotechnology, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy
5Department of Food and Nutrition, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
6Geriatrics Unit, Azienda ULSS 16 Padova, S. Antonio Hospital, Via Facciolati 71, 35127 Padova, Italy

Received 13 November 2013; Accepted 13 December 2013; Published 12 January 2014

Academic Editor: Cristina Angeloni

Copyright © 2014 Carlo Cervellati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer’s disease (LOAD). It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD. The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and/or serum antioxidant capacity might be predictive of the clinical progression of MCI to LOAD. The levels of these two markers were measured in 111 patients with MCI (follow-up: years), 105 patients with LOAD, and 118 nondemented healthy controls. Multivariate analysis adjusted for potential confounding factors, including age, gender, smoking, and comorbidities, showed a significant increase () in baseline levels of OxS in MCI and LOAD as compared to cognitive healthy controls. No differences in either of OxS markers were found by comparing MCI patients who converted () or not converted () to LOAD. Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD. However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations.