BioMed Research International

Redox Signaling in Degenerative Diseases: From Molecular Mechanisms to Health Implications


Publishing date
04 Apr 2014
Status
Published
Submission deadline
15 Nov 2013

1Department of Life Quality Studies, Alma Mater Studiorum University of Bologna, Italy

2Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy

3Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK


Redox Signaling in Degenerative Diseases: From Molecular Mechanisms to Health Implications

Description

Maintenance of normal intracellular redox status plays an important role in regulating many physiological processes. The cellular oxidation and reduction environment is influenced by the production and removal of reactive oxygen species (ROS). Unbalanced levels of ROS are a common characteristic of many acute and chronic degenerative diseases such as cancer, cardiovascular diseases, type II diabetes, acute liver, renal failure, and neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases and stroke. On the other hand, in the last years it has been shown that ROS are not only detrimental to cells but at physiological level regulate a myriad of cellular processes including transcription regulation and cell signaling. Several reports support the hypothesis that cellular ROS levels could function as “second messengers.” The second-messenger properties of ROS are believed to activate signaling pathways by regulating kinases, phosphatases, transcription factors, or ion channels to coordinate the final response of the cell. Understanding the cross talk between signaling, ROS, and cell homeostasis is fundamental for understanding redox biology and disease pathogenesis.

Full length original research articles as well as review articles that report the mechanisms behind redox imbalance leading to signaling alteration and their involvement in the onset of degenerative diseases are particularly welcome. Moreover, papers dealing with the therapeutic strategies to restore the redox balance and the signaling pathways to slow or halt these diseases will also be considered. Potential topics include, but are not limited to:

  • Role of ROS in molecular signaling
  • Redox signaling in heart failure
  • Redox regulation of stem cell signaling
  • Redox regulation of angiogenesis
  • Redox signaling in neurodegenerative disease
  • Redox signaling in inflammation
  • Redox signaling in aging
  • Redox signaling modulation to counteract degenerative diseases

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/biochemistry/rsdd/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2014
  • - Article ID 245761
  • - Editorial

Redox Signaling in Degenerative Diseases: From Molecular Mechanisms to Health Implications

Cristina Angeloni | Tullia Maraldi | David Vauzour
  • Special Issue
  • - Volume 2014
  • - Article ID 191767
  • - Research Article

Oxygen Radicals Elicit Paralysis and Collapse of Spinal Cord Neuron Growth Cones upon Exposure to Proinflammatory Cytokines

Thomas B. Kuhn
  • Special Issue
  • - Volume 2014
  • - Article ID 209845
  • - Review Article

A Paradoxical Chemoresistance and Tumor Suppressive Role of Antioxidant in Solid Cancer Cells: A Strange Case of Dr. Jekyll and Mr. Hyde

Jolie Kiemlian Kwee
  • Special Issue
  • - Volume 2014
  • - Article ID 328959
  • - Research Article

A Short-Term Incubation with High Glucose Impairs VASP Phosphorylation at Serine 239 in response to the Nitric Oxide/cGMP Pathway in Vascular Smooth Muscle Cells: Role of Oxidative Stress

Isabella Russo | Michela Viretto | ... | Mariella Trovati
  • Special Issue
  • - Volume 2014
  • - Article ID 857504
  • - Research Article

Role of Plasma Membrane Caveolae/Lipid Rafts in VEGF-Induced Redox Signaling in Human Leukemia Cells

Cristiana Caliceti | Laura Zambonin | ... | Cecilia Prata
  • Special Issue
  • - Volume 2014
  • - Article ID 238485
  • - Review Article

Role of Methylglyoxal in Alzheimer’s Disease

Cristina Angeloni | Laura Zambonin | Silvana Hrelia
  • Special Issue
  • - Volume 2014
  • - Article ID 546453
  • - Research Article

PPAR-γ Impairment Alters Peroxisome Functionality in Primary Astrocyte Cell Cultures

Lorenzo Di Cesare Mannelli | Matteo Zanardelli | ... | Carla Ghelardini
  • Special Issue
  • - Volume 2014
  • - Article ID 456937
  • - Research Article

Nuclear Nox4-Derived Reactive Oxygen Species in Myelodysplastic Syndromes

Marianna Guida | Tullia Maraldi | ... | Anto De Pol
  • Special Issue
  • - Volume 2014
  • - Article ID 131737
  • - Review Article

Redox Signaling as a Therapeutic Target to Inhibit Myofibroblast Activation in Degenerative Fibrotic Disease

Natalie Sampson | Peter Berger | Christoph Zenzmaier
  • Special Issue
  • - Volume 2014
  • - Article ID 318714
  • - Review Article

ROS, Notch, and Wnt Signaling Pathways: Crosstalk between Three Major Regulators of Cardiovascular Biology

C. Caliceti | P. Nigro | ... | R. Ferrari
BioMed Research International
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