BioMed Research International / 2014 / Article / Tab 2

Review Article

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

Table 2

The activity and pathophysiological roles of AMPK in kidney disease.

Experimental type AMPK activity and Renal outcome Mechanism Reference

Diabetic models
 STZ-diabetic rats AMPK expression↑, AMPK activity↓ Unclear Cammisotto et al. [32]
 STZ-diabetic rats AMPK activity↓ Plasma adiponectin↓ Guo and Zhao [33]
 Treatment of AICAR and metformin (STZ-diabetic rats) AMPK activity↑, renal hypertrophy↓ Unclear Lee et al. [34]
 Db/db mice AMPK activity↓ Unclear Kitada et al. [35]
 High-fat diet-induced obese mice AMPK activity↓, renal lipogenesis↑ Unclear Kume et al. [36]
 Treatment of AICARAMPK activity↑,
Albuminuria↓, and glomerular lesion↓
Improvement of mitochondria dysfunctionDugan et al. [37]
Nondiabetic models
 Adiponectin−/− mice AMPK activity↓ in podocytes Adiponectin deficiency Sharma et al. [38]
 Treatment of adiponectin and AICAR AMPK activity↑ (podocytes, mesangial cells, and glomerular endothelial cells) Adiponectin receptor-dependent Cammisotto and Bendayan [39]

STZ; streptozotocin, AICAR: 5-aminoimidazole-4-carboxamide-1- -d-ribofuranoside.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.