BioMed Research International / 2014 / Article / Tab 3

Review Article

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

Table 3

The activity and pathophysiological roles of Sirt1 in kidney disease.

Experimental type Renal outcome/phenotype Mechanism Reference

Activity/expression
 STZ-diabetic rats Sirt1 expressionUnclear Tikoo et al. [40]
 STZ-diabetic rats Sirt1 expression↓ Unclear Li et al. [41]
 Db/db mice Sirt1 expression→ Unclear Kitada et al. [35]
 Calorie-restricted rats Sirt1 expression↑Insulin/IGF-1↓Cohen et al. [42]
 STZ- and db/db miceSirt1 expression↓NMN depletionHasegawa et al. [43]
Pathophysiological roles
 Sirt1+/− mice (PTECs) Renal aging↑ Autophagy deficiency Kume et al. [16]
 Sirt1+/− mice (Medullary cells) UUO-induced renal fibrosis↑ Decrease of Cox2 expression He et al. [44]
 PTECs-specific Sirt1-TG mice ROS- and cisplatin-induced PTECs damage↓ Increase of catalase expression Hasegawa et al. [45]
 Treatment with resveratrol UUO-induced fibrosis↓ Suppression of TGF -Smad3 pathway Li et al. [46]
 Sirt1 overexpression (mesangial cells) ROS-induced apoptosis↓ Inactivation of p53 Kume et al. [47]
 Sirt1 overexpression (mesangial cells) TGF -induced apoptosis↓ Inactivation of Smad7 Kume et al. [48]
 Treatment of SRT1720 (PTECs) Mitochondrial biogenesis↑, ROS↓Activation of PGC-1 Funk et al. [49]
 PTECs-specific Sirt1-TG miceDiabetes-induced podocyte injury↓Epigenetic mechanismHasegawa et al. [43]

STZ; streptozotocin, PTECs: proximal tubular epithelial cells, ROS: reactive oxygen species, UUO: unilateral ureteral obstruction, TGF : transforming growth factor , IGF-1: insulin-like growth factor 1, Cox2: cyclooxygenase 2, PGC-1 : peroxisome proliferator-activated receptor coactivator-1 , and NMN; nicotinamide mononucleotide.

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