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BioMed Research International
Volume 2014, Article ID 383494, 6 pages
http://dx.doi.org/10.1155/2014/383494
Research Article

Correlation between Behavioural and Psychological Symptoms of Alzheimer Type Dementia and Plasma Homocysteine Concentration

1Department of Geriatric, Qingdao Mental Health Center, Qingdao 266034, China
2Office of Director of Hospital, Qingdao Mental Health Center, Qingdao 266034, China

Received 16 January 2014; Accepted 19 May 2014; Published 4 June 2014

Academic Editor: Jin-Tai Yu

Copyright © 2014 Zhanjie Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. A. Fuentealba, G. Farias, J. Scheu, M. Bronfman, M. P. Marzolo, and N. C. Inestrosa, “Signal transduction during amyloid-β-peptide neurotoxicity: role in Alzheimer disease,” Brain Research Reviews, vol. 47, no. 1–3, pp. 275–289, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. I. P. Association, “Research methodological issue in evaluating behavioral disorders of dementia,” International Psychogeriatrics, vol. 8, no. 3, pp. 215–218, 1996. View at Google Scholar
  3. H. F. Qu, H. Zhang, J. H. Sheng, and Z. X. Gao, “Comparison of the behavioral disorder in Alzheimer's disease and vascular dementia patients,” Journal of Clinical Psychological Medicine, vol. 13, no. 5, pp. 287–288, 2003. View at Google Scholar
  4. P. Tariot and L. Blazina, “The psychopathology of dementia,” Neurological Disease and Therapy, vol. 22, no. 1, p. 461, 1994. View at Google Scholar
  5. J. Wei and H. W. Li, “Progress in clinical research of Alzheimer's disease,” Journal of Qiqihar Medical College, vol. 29, no. 21, p. 2633, 2008. View at Google Scholar
  6. M. Piccininni, A. di Carlo, M. Baldereschi, G. Zaccara, and D. Inzitari, “Behavioral and psychological symptoms in Alzheimer's disease: frequency and relationship with duration and severity of the disease,” Dementia and Geriatric Cognitive Disorders, vol. 19, no. 5-6, pp. 276–281, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Steinberg, J.-M. Sheppard, J. T. Tschanz et al., “The incidence of mental and behavioral disturbances in dementia: the Cache County Study,” The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 15, no. 3, pp. 340–345, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Rymer, S. Salloway, L. Norton, P. Malloy, S. Correia, and D. Monast, “Impaired awareness, behavior disturbance, and caregiver burden in Alzheimer disease,” Alzheimer Disease & Associated Disorders, vol. 16, no. 4, pp. 248–253, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Quadri, C. Fragiacomo, R. Pezzati et al., “Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia,” The American Journal of Clinical Nutrition, vol. 80, no. 1, pp. 114–122, 2004. View at Google Scholar · View at Scopus
  10. H. J. Stuerenburg, T. Mueller-Thomsen, and A. Methner, “Vitamin B12 plasma concentrations in Alzheimier disease,” Neuroendocrinology Letters, vol. 25, no. 3, pp. 176–177, 2004. View at Google Scholar · View at Scopus
  11. T. Bottiglieri, “Folate, vitamin B12, and neuropsychiatric disorders,” Nutrition Reviews, vol. 54, no. 12, pp. 382–390, 1996. View at Google Scholar · View at Scopus
  12. S. Engelborghs, E. Vloeberghs, K. Maertens et al., “Correlations between cognitive, behavioural and psychological findings and levels of vitamin B12 and folate in patients with dementia,” International Journal of Geriatric Psychiatry, vol. 19, no. 4, pp. 365–370, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. E. M. Whyte, B. H. Mulsant, M. A. Butters et al., “Cognitive and behavioral correlates of low vitamin B12 levels in elderly patients with progressive dementia,” The American Journal of Geriatric Psychiatry, vol. 10, no. 3, pp. 321–327, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Nilsson, L. Gustafson, and B. Hultberg, “Plasma homocysteine is a sensitive marker for tissue deficiency of both cobalamines and folates in a psychogeriatric population,” Dementia and Geriatric Cognitive Disorders, vol. 10, no. 6, pp. 476–482, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. P. I. Ho, D. Ortiz, E. Rogers, and T. B. Shea, “Multiple aspects of homocysteine neurotoxicity: glutamate excitotoxicity, kinase hyperactivation and DNA damage,” Journal of Neuroscience Research, vol. 70, no. 5, pp. 694–702, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Fácila, J. E. Nuñez, V. Bertomeu G. et al., “Early determination of homocysteine levels in acute coronary syndromes, is it an independent prognostic factor?” International Journal of Cardiology, vol. 100, no. 2, pp. 275–279, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. J. K. Virtanen, S. Voutilainen, P. Happonen et al., “Serum homocysteine, folate and risk of stroke: Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study,” European Journal of Cardiovascular Prevention and Rehabilitation, vol. 12, no. 4, pp. 369–375, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Adunsky, Z. Arinzon, Z. Fidelman, I. Krasniansky, M. Arad, and R. Gepstein, “Plasma homocysteine levels and cognitive status in long-term stay geriatric patients: a cross-sectional study,” Archives of Gerontology and Geriatrics, vol. 40, no. 2, pp. 129–138, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Reif, B. Pfuhlmann, and K.-P. Lesch, “Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses,” Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 29, no. 7, pp. 1162–1168, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. K. Qian, C. X. Jiang, and X. D. Du, “Relationship between plasma homocysteine, serum folate levels and first-episode schizophrenic patients,” Suzhou University Journal of Medical Science, vol. 29, no. 6, pp. 1140–1142, 2009. View at Google Scholar
  21. C.-S. Chen, J.-C. Tsai, H.-Y. Tsang et al., “Homocysteine levels, MTHFR C677T genotype, and MRI hyperintensities in late-onset major depressive disorder,” The American Journal of Geriatric Psychiatry, vol. 13, no. 10, pp. 869–875, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Atmaca, E. Tezcan, M. Kuloglu, O. Kirtas, and B. Ustundag, “Serum folate and homocysteine levels in patients with obsessive-compulsive disorder,” Psychiatry and Clinical Neurosciences, vol. 59, no. 5, pp. 616–620, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. B. Regland, L. Abrahamsson, K. Blennow, B. Grenfeldt, and C.-G. Gottfries, “CSF-methionine is elevated in psychotic patients,” Journal of Neural Transmission, vol. 111, no. 5, pp. 631–640, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Tabet, H. Rafi, G. Weaving, B. Lyons, and S. Iversen, “Behavioural and psychological symptoms of Alzheimer type dementia are not correlated with plasma homocysteine concentration,” Dementia and Geriatric Cognitive Disorders, vol. 22, no. 5-6, pp. 432–438, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. A. McCaddon, P. Hudson, G. Davies, A. Hughes, J. H. Williams, and C. Wilkinson, “Homocysteine and cognitive decline in healthy elderly,” Dementia and Geriatric Cognitive Disorders, vol. 12, no. 5, pp. 309–313, 2001. View at Publisher · View at Google Scholar · View at Scopus
  26. J. H. Schafer, T. A. Glass, K. I. Bolla, M. Mintz, A. E. Jedlicka, and B. S. Schwartz, “Homocysteine and cognitive function in a population-based study of older adults,” Journal of the American Geriatrics Society, vol. 53, no. 3, pp. 381–388, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. M. M. Budge, C. de Jager, E. Hogervorst, and A. D. Smith, “Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people,” Journal of the American Geriatrics Society, vol. 50, no. 12, pp. 2014–2018, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Prins, T. den Heijer, A. Hofman et al., “Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study,” Neurology, vol. 59, no. 9, pp. 1375–1380, 2002. View at Google Scholar · View at Scopus
  29. K. Nilsson, L. Gustafson, and B. Hultberg, “Relation between plasma homocysteine and Alzheimer's disease,” Dementia and Geriatric Cognitive Disorders, vol. 14, no. 1, pp. 7–12, 2002. View at Publisher · View at Google Scholar · View at Scopus