The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma

Table 1

Target genes that are transcriptionally activated by HIF-1 in cancer progression.

Effect on cancer progression	Target genes of HIF-1	References
Angiogenesis	VEGF, NOS, ET1, SDF1, ANGPT2, PDGF, leptin	[21–27]
Glucose metabolism	GLUT1, HK, LDHA, MCT4, PDK1, MXI1	[31–36]
Cell proliferation	NOS, IGF-2, TGF, C-MYC, ID2	[22, 37–40]
Cell apoptosis	p53, BNIP3, Caspase 3	[41–43]
Invasion and metastasis	MMP2, FN1, C-MET, AMF, KRT14	[44–48]