Modulation of Steroidogenic Pathway in Rat Granulosa Cells with Subclinical Cd Exposure and Insulin Resistance: An Impact on Female Fertility

Table 3

Summary of the results.

Parameters	Groups
	Cd	IR	IR + Cd
IR status	—	↓↓↓	↓↓↓
Serum estradiol	↓	↓↓	↓↓
Histology	Fibrosis	Fibrosis and thickening	Fibrosis and thickening
Granulosa cell viability	↓	↓	↓↓
StAR-mRNA	↓↓↓	—	—
StAR-protein	↓↓↓	↓↓	↓↓
CYP19 A1-mRNA	↓↓	↓↓	↓ (ns)
CYP19 A1-protein	↓↓	↓↓	↓ (ns)
17- HSD-mRNA	—	—	—
17- HSD-protein	↓	↓↓	↓↓

(— represents no change, down arrow represents downregulation, and ns represents nonsignificant).