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BioMed Research International
Volume 2014 (2014), Article ID 504727, 6 pages
Research Article

An Association Study between Genetic Polymorphism in the Interleukin-6 Receptor Gene and Coronary Heart Disease

1Ningbo Medical Center, Lihuili Hospital, Ningbo University, 57 Xingning Road, Ningbo, Zhejiang 315211, China
2School of Medicine, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315211, China

Received 7 February 2014; Revised 9 April 2014; Accepted 16 April 2014; Published 26 May 2014

Academic Editor: Hongwei Wang

Copyright © 2014 Jiangqing Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis. Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese ( ). However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans ( , odds ratio = 0.93, 95% confidential interval = 0.89–0.96). Since there is significant difference among different populations, further studies are warranted to test the contribution of rs7529229 to CHD in other ethnic populations.