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BioMed Research International
Volume 2014, Article ID 536510, 6 pages
http://dx.doi.org/10.1155/2014/536510
Research Article

Insulin Preconditioning Elevates p-Akt and Cardiac Contractility after Reperfusion in the Isolated Ischemic Rat Heart

1Department of Anaesthesia, Royal Victoria Hospital, McGill University Health Center, Montreal, QC, Canada H3A 1A1
2Outcomes Research Consortium, Cleveland, OH 44195, USA
3Department of Anesthesiology, Yamanashi University, Yamanashi 409-3821, Japan

Received 13 June 2014; Accepted 1 August 2014; Published 13 August 2014

Academic Editor: M.-Saadeh Suleiman

Copyright © 2014 Tamaki Sato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. E. Murry, R. B. Jennings, and K. A. Reimer, “Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium,” Circulation, vol. 74, no. 5, pp. 1124–1136, 1986. View at Publisher · View at Google Scholar · View at Scopus
  2. R. F. Davis, L. W. V. DeBoer, R. E. Rude, E. Lowenstein, and P. R. Maroko, “The effect of halothane anesthesia on myocardial necrosis, hemodynamic performance, and regional myocardial blood flow in dogs following coronary artery occlusion,” Anesthesiology, vol. 59, no. 5, pp. 402–411, 1983. View at Publisher · View at Google Scholar · View at Scopus
  3. D. C. Warltier, M. H. Al-Wathiqui, J. P. Kampine, and W. T. Schmeling, “Recovery of contractile function of stunned myocardium in chronically instrumented dogs is enhanced by halothane or isoflurane,” Anesthesiology, vol. 69, no. 4, pp. 552–565, 1988. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Marijic, D. F. Stowe, L. A. Turner, J. P. Kampine, and Z. J. Bosnjak, “Differential protective effects of halothane and isoflurane against hypoxic and reoxygenation injury in the isolated guinea pig heart,” Anesthesiology, vol. 73, no. 5, pp. 976–983, 1990. View at Publisher · View at Google Scholar · View at Scopus
  5. M. W. Bienengraeber, D. Weihrauch, J. R. Kersten, P. S. Pagel, and D. C. Warltier, “Cardioprotection by volatile anesthetics,” Vascular Pharmacology, vol. 42, no. 5-6, pp. 243–252, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Sato, R. Hatzakorzian, G. Carvalho et al., “High-dose insulin administration improves left ventricular function after coronary artery bypass graft surgery,” Journal of Cardiothoracic and Vascular Anesthesia, vol. 25, no. 6, pp. 1086–1091, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Carvalho, P. Pelletier, T. Albacker et al., “Cardioprotective effects of glucose and insulin administration while maintaining normoglycemia (GIN therapy) in patients undergoing coronary artery bypass grafting,” The Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 5, pp. 1469–1477, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. A. K. Jonassen, E. Aasum, R. A. Riemersma, O. D. Mjøs, and T. S. Larsen, “Glucose-insulin-potassium reduces infarct size when administered during reperfusion,” Cardiovascular Drugs and Therapy, vol. 14, no. 6, pp. 615–623, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. A. K. Jonassen, O. D. Mjøs, and M. N. Sack, “p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling,” Biochemical and Biophysical Research Communications, vol. 315, no. 1, pp. 160–165, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. A. K. Jonassen, M. N. Sack, O. D. Mjøs, and D. M. Yellon, “Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling,” Circulation Research, vol. 89, no. 12, pp. 1191–1198, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. H. F. Zhang, Q. Fan, X. X. Qian et al., “Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion,” Apoptosis, vol. 9, no. 6, pp. 777–783, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Ofir, M. Arad, E. Porat et al., “Increased glycogen stores due to γ-AMPK overexpression protects against ischemia and reperfusion damage,” Biochemical Pharmacology, vol. 75, no. 7, pp. 1482–1491, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Iliadis, N. Kadoglou, and T. Didangelos, “Insulin and the heart,” Diabetes Research and Clinical Practice, vol. 93, no. 1, pp. S86–S91, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Bertrand, S. Horman, C. Beauloye, and J. Vanoverschelde, “Insulin signalling in the heart,” Cardiovascular Research, vol. 79, no. 2, pp. 238–248, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. A. K. Jonassen, B. K. Brar, O. D. Mjøs, M. N. Sack, D. S. Latchman, and D. M. Yellon, “Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism,” Journal of Molecular and Cellular Cardiology, vol. 32, no. 5, pp. 757–764, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. Z. Q. Zhao, J. S. Corvera, M. E. Halkos et al., “Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning,” American Journal of Physiology Heart and Circulatory Physiology, vol. 285, no. 2, pp. H579–H588, 2003. View at Google Scholar
  17. T. Matsui, J. Tao, F. Del Monte et al., “Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo,” Circulation, vol. 104, no. 3, pp. 330–335, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. M. M. Mocanu, R. M. Bell, and D. M. Yellon, “PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning,” Journal of Molecular and Cellular Cardiology, vol. 34, no. 6, pp. 661–668, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Alvarez-Tejado, S. Naranjo-Suárez, C. Jiménez, A. C. Carrera, M. O. Landázuri, and L. Del Peso, “Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells. Protective role in apoptosis,” The Journal of Biological Chemistry, vol. 276, no. 25, pp. 22368–22374, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. B. N. Fuglesteg, C. Tiron, A. K. Jonassen, O. D. Mjøs, and K. Ytrehus, “Pretreatment with insulin before ischaemia reduces infarct size in Langendorff-perfused rat hearts,” Acta Physiologica, vol. 195, no. 2, pp. 273–282, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Frank, M. Bonney, S. Bonney, L. Weitzel, M. Koeppen, and T. Eckle, “Myocardial ischemia reperfusion injury: from basic science to clinical bedside,” Seminars in Cardiothoracic and Vascular Anesthesia, vol. 16, no. 3, pp. 123–132, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. B. S. Cain, D. R. Meldrum, C. A. Dinarello et al., “Tumor necrosis factor-α and interleukin-1β synergistically depress human myocardial function,” Critical Care Medicine, vol. 27, no. 7, pp. 1309–1318, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Kleinbongard, R. Schulz, and G. Heusch, “TNFα in myocardial ischemia/reperfusion, remodeling and heart failure,” Heart Failure Reviews, vol. 16, no. 1, pp. 49–69, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. X. Li, W. Cao, T. Li et al., “Amlodipine inhibits TNF-α production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway,” International Immunopharmacology, vol. 9, no. 9, pp. 1032–1041, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. C. S. Apstein and L. H. Opie, “A challenge to the metabolic approach to myocardial ischaemia,” European Heart Journal, vol. 26, no. 10, pp. 956–959, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. D. J. Hausenloy and D. M. Yellon, “Preconditioning and postconditioning: united at reperfusion,” Pharmacology and Therapeutics, vol. 116, no. 2, pp. 173–191, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Imagawa, G. F. Baxter, and D. M. Yellon, “Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo,” Journal of Cardiovascular Pharmacology, vol. 31, no. 1, pp. 74–79, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Oral, G. W. Dorn II, and D. L. Mann, “Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-α in the adult mammalian cardiac myocyte,” The Journal of Biological Chemistry, vol. 272, no. 8, pp. 4836–4842, 1997. View at Publisher · View at Google Scholar · View at Scopus
  29. B. S. Cain, A. H. Harken, and D. R. Meldrum, “Therapeutic strategies to reduce TNF-α mediated cardiac contractile depression following ischemia and reperfusion,” Journal of Molecular and Cellular Cardiology, vol. 31, no. 5, pp. 931–947, 1999. View at Publisher · View at Google Scholar · View at Scopus