-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway
α-Mangostin induces cell cycle arrest in pancreatic cancer cells. (a) The effect of α-mangostin on cell cycle progression in pancreatic cancer cells was assessed by flow cytometry. Cells were fixed, stained, and analyzed for DNA content. (b) The distribution and percentage of cells in G1/G0, S and G2/M phase of the cell cycle are indicated. (c) Protein levels of cyclin-D3 and cyclin-D1 were assessed by Western blotting with β-actin as loading control.