BioMed Research International / 2014 / Article / Fig 5

Research Article

-Mangostin Suppresses the Viability and Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells by Downregulating the PI3K/Akt Pathway

Figure 5

α-Mangostin modulates the expression of EMT-related genes in pancreatic cancer cells cells. (a) Panc-1 and BxPC-3 cells were treated with α-mangostin 16 μM at the indicated concentrations for 24 h. Protein (a) and mRNA (b) levels of MMP-2, MMP-9, E-cadherin, vimentin, and N-cadherin were measured by Western blotting and qRT-PCR, respectively. compared with controls.