Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII
Figure 6
The dockingof compounds 3 (purple) and 4 (gray) into the active site of CA II (a) and CA XII (b). The solvent accessible surface of the protein is displayed to demonstrate how well the ligand fits the active site of CA II. Compound tails are arranged quite differently in CAs II and XII. The protein surface is colored to show oxygen atoms (red), nitrogen atoms (blue), and zinc atom (gray), and the rest is in cyan-blue.
