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BioMed Research International
Volume 2014, Article ID 697935, 12 pages
Review Article

Neuropathologic Implication of Peripheral Neuregulin-1 and EGF Signals in Dopaminergic Dysfunction and Behavioral Deficits Relevant to Schizophrenia: Their Target Cells and Time Window

Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8585, Japan

Received 1 February 2014; Accepted 10 April 2014; Published 13 May 2014

Academic Editor: Saverio Bellusci

Copyright © 2014 Hiroyuki Nawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • Tadasato Nagano, Makoto Mizuno, Keisuke Morita, and Hiroyuki Nawa, “Pathological Implications of Oxidative Stress in Patients and Animal Models with Schizophrenia: The Role of Epidermal Growth Factor Receptor Signaling,” Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology, vol. 29, pp. 429–446, 2015. View at Publisher · View at Google Scholar
  • Mizuki Hino, Yasuto Kunii, Junya Matsumoto, Akira Wada, Atsuko Nagaoka, Shin-ichi Niwa, Hitoshi Takahashi, Akiyoshi Kakita, Hiroyasu Akatsu, Yoshio Hashizume, Sakon Yamamoto, and Hirooki Yabe, “Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia,” Journal of Psychiatric Research, 2016. View at Publisher · View at Google Scholar
  • Md Shaki Mostaid, David Lloyd, Benny Liberg, Suresh Sundram, Avril Pereira, Christos Pantelis, Tim Karl, Cynthia Shannon Weickert, Ian P. Everall, and Chad A. Bousman, “Neuregulin-1 and schizophrenia in the genome-wide association study era,” Neuroscience & Biobehavioral Reviews, 2016. View at Publisher · View at Google Scholar
  • Junsu Kang, Jianxin Hu, Ravi Karra, Amy L. Dickson, Valerie A. Tornini, Gregory Nachtrab, Matthew Gemberling, Joseph A. Goldman, Brian L. Black, and Kenneth D. Poss, “Modulation of tissue repair by regeneration enhancer elements,” Nature, vol. 532, no. 7598, pp. 201–+, 2016. View at Publisher · View at Google Scholar
  • Hisaaki Namba, Takeshi Okubo, and Hiroyuki Nawa, “Perinatal Exposure to Neuregulin-1 Results in Disinhibition of Adult Midbrain Dopaminergic Neurons: Implication in Schizophrenia Modeling,” Scientific Reports, vol. 6, pp. 22606, 2016. View at Publisher · View at Google Scholar
  • Jhih-Rong Lin, Ying Cai, Quanwei Zhang, Zhengdong D. Zhang, Wen Zhang, and Rubén Nogales-Cadenas, “Integrated post-GWAS analysis sheds new light on the disease mechanisms of schizophrenia,” Genetics, vol. 204, no. 4, pp. 1587–1600, 2016. View at Publisher · View at Google Scholar
  • Lieve Desbonnet, “Mouse Models of Schizophrenia,” Modeling the Psychopathological Dimensions of Schizophrenia - From Molecules to Behavior, vol. 23, pp. 267–284, 2016. View at Publisher · View at Google Scholar
  • Hisaaki Namba, Tadasato Nagano, Eiichi Jodo, Satoshi Eifuku, Masao Horie, Hirohide Takebayashi, Yuriko Iwakura, Hidekazu Sotoyama, Nobuyuki Takei, and Hiroyuki Nawa, “Epidermal growth factor signals attenuate phenotypic and functional development of neocortical GABA neurons,” Journal of Neurochemistry, 2017. View at Publisher · View at Google Scholar
  • Mithilesh Kumar Jha, Jong-Heon Kim, Gyun Jee Song, Won-Ha Lee, In-Kyu Lee, Ho-Won Lee, Seong Soo A. An, SangYun Kim, and Kyoungho Suk, “Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases,” Progress in Neurobiology, 2017. View at Publisher · View at Google Scholar
  • Yue Hei, Rong Chen, Xicai Yi, Lizhou Wei, Qianfa Long, and Weiping Liu, “The Expression of Hippocampal NRG1/ErbB4 Correlates With Neuronal Apoptosis, but Not With Glial Activation During Chronic Cerebral Hypoperfusion,” Frontiers in Aging Neuroscience, vol. 10, 2018. View at Publisher · View at Google Scholar
  • Carlos Zapata-Martín del Campo, Martín Martínez-Rosas, and Verónica Guarner-Lans, “Epigenetic Programming of Synthesis, Release, and/or Receptor Expression of Common Mediators Participating in the Risk/Resilience for Comorbid Stress-Related Disorders and Coronary Artery Disease,” International Journal of Molecular Sciences, vol. 19, no. 4, pp. 1224, 2018. View at Publisher · View at Google Scholar
  • Eiichi Jodo, Hiroyoshi Inaba, Itaru Narihara, Hidekazu Sotoyama, Eiko Kitayama, Hirooki Yabe, Hisaaki Namba, Satoshi Eifuku, and Hiroyuki Nawa, “Neonatal exposure to an inflammatory cytokine, epidermal growth factor, results in the deficits of mismatch negativity in rats,” Scientific Reports, vol. 9, no. 1, 2019. View at Publisher · View at Google Scholar