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BioMed Research International
Volume 2014, Article ID 723176, 8 pages
http://dx.doi.org/10.1155/2014/723176
Research Article

Correlation of Altered Expression of the Autophagy Marker LC3B with Poor Prognosis in Astrocytoma

1Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan
2Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
4Department of Pathology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
5Department of Surgery, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 807, Taiwan
6Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
7Department of Surgery, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan
9Acupuncture Research Center, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan

Received 28 February 2014; Accepted 10 April 2014; Published 12 May 2014

Academic Editor: Hung-Chen Wang

Copyright © 2014 Daniel Winardi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. N. Louis, H. Ohgaki, O. D. Wiestler et al., “The 2007 WHO classification of tumours of the central nervous system,” Acta Neuropathologica, vol. 114, no. 2, pp. 97–109, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. El-Sayed and M. M. Taha, “Immunohistochemical expression of cycloxygenase-2 in astrocytoma: correlation with angiogenesis, tumor progression and survival,” Turkish Neurosurgery, vol. 21, no. 1, pp. 27–35, 2011. View at Google Scholar · View at Scopus
  3. V. Santosh, A. Arivazhagan, P. Sreekanthreddy et al., “Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma,” Cancer Epidemiology Biomarkers & Prevention, vol. 19, no. 6, pp. 1399–1408, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Maiti, K. Ghosh, U. Chatterjee, S. Chakrobarti, S. Chatterjee, and S. Basu, “Epidermal growth factor receptor and proliferating cell nuclear antigen in astrocytomas,” Neurology India, vol. 56, no. 4, pp. 456–462, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Castillo, J. K. Smith, and L. Kwock, “Correlation of myo-inositol levels and grading of cerebral astrocytomas,” American Journal of Neuroradiology, vol. 21, no. 9, pp. 1645–1649, 2000. View at Google Scholar · View at Scopus
  6. L. Li, J. Wang, X. Shen et al., “Expression and prognostic value of NDRG2 in human astrocytomas,” Journal of the Neurological Sciences, vol. 308, no. 1-2, pp. 77–82, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. T. Reya, S. J. Morrison, M. F. Clarke, and I. L. Weissman, “Stem cells, cancer, and cancer stem cells,” Nature, vol. 414, no. 6859, pp. 105–111, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. S. K. Singh, I. D. Clarke, M. Terasaki et al., “Identification of a cancer stem cell in human brain tumors,” Cancer Research, vol. 63, no. 18, pp. 5821–5828, 2003. View at Google Scholar · View at Scopus
  9. G. Liu, X. Yuan, Z. Zeng et al., “Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma,” Molecular Cancer, vol. 5, article 67, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Bao, Q. Wu, R. E. McLendon et al., “Glioma stem cells promote radioresistance by preferential activation of the DNA damage response,” Nature, vol. 444, no. 7120, pp. 756–760, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Fu, Z.-G. Liu, X.-M. Liu et al., “Glioblastoma stem cells resistant to temozolomide-induced autophagy,” Chinese Medical Journal, vol. 122, no. 11, pp. 1255–1259, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Yang and D. J. Klionsky, “An overview of the molecular mechanism of autophagy,” Current Topics in Microbiology and Immunology, vol. 335, no. 1, pp. 1–32, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. A. C. Kimmelman, “The dynamic nature of autophagy in cancer,” Genes and Development, vol. 25, no. 19, pp. 1999–2010, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. C.-P. Kung, A. Budina, G. Balaburski, M. K. Bergenstock, and M. E. Murphy, “Autophagy in tumor suppression and cancer therapy,” Critical Reviews in Eukaryotic Gene Expression, vol. 21, no. 1, pp. 71–100, 2011. View at Google Scholar · View at Scopus
  15. K. S. Choi, “Autophagy and cancer,” Experimental and Molecular Medicine, vol. 44, no. 2, pp. 109–120, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Pankiv, T. H. Clausen, T. Lamark et al., “p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy*,” The Journal of Biological Chemistry, vol. 282, no. 33, pp. 24131–24145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Satoo, N. N. Noda, H. Kumeta et al., “The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy,” The EMBO Journal, vol. 28, no. 9, pp. 1341–1350, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. R. A. Hanna, M. N. Quinsay, A. M. Orogo, K. Giang, S. Rikka, and A. B. Gustafsson, “Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy,” The Journal of Biological Chemistry, vol. 287, no. 23, pp. 19094–19104, 2012. View at Google Scholar
  19. X. H. Liang, J. Yu, K. Brown, and B. Levine, “Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function,” Cancer Research, vol. 61, no. 8, pp. 3443–3449, 2001. View at Google Scholar · View at Scopus
  20. S. Shrivastava, J. Bhanja Chowdhury, R. Steele, R. Ray, and R. B. Ray, “Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling,” Journal of Virology, vol. 86, pp. 8705–8712, 2012. View at Google Scholar
  21. A. U. Gurkar, K. Chu, L. Raj et al., “Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress,” Nature Communications, vol. 4, p. 2189, 2013. View at Google Scholar
  22. S. Chen, Y. Z. Jiang, L. Huang et al., “The residual tumor autophagy marker LC3B serves as a prognostic marker in local advanced breast cancer after neoadjuvant chemotherapy,” Clinical Cancer Research, vol. 19, pp. 6853–6862, 2013. View at Google Scholar
  23. S. Hombach-Klonisch, T. Paranjothy, E. Wiechec et al., “Cancer stem cells as targets for cancer therapy: selected cancers as examples,” Archivum Immunologiae et Therapiae Experimentalis, vol. 56, no. 3, pp. 165–180, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. A. U. Ahmed, N. G. Alexiades, and M. S. Lesniak, “The use of neural stem cells in cancer gene therapy: predicting the path to the clinic,” Current Opinion in Molecular Therapeutics, vol. 12, no. 5, pp. 546–552, 2010. View at Google Scholar · View at Scopus
  25. S. Bidlingmaier, X. Zhu, and B. Liu, “The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells,” Journal of Molecular Medicine, vol. 86, no. 9, pp. 1025–1032, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. F. Ren, W. Q. Sheng, and X. Du, “CD133: a cancer stem cells marker, is used in colorectal cancers,” World Journal of Gastroenterology, vol. 19, pp. 2603–2611, 2013. View at Google Scholar
  27. X. Huang, H.-M. Bai, L. Chen, B. Li, and Y.-C. Lu, “Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors,” Journal of Clinical Neuroscience, vol. 17, no. 12, pp. 1515–1519, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Melguizo, J. Prados, B. Gonzalez et al., “MGMT promoter methylation status and MGMT and CD133 immunohistochemical expression as prognostic markers in glioblastoma patients treated with temozolomide plus radiotherapy,” Journal of Translational Medicine, vol. 10, article 250, 2012. View at Publisher · View at Google Scholar
  29. J. W. Yates, B. Chalmer, and F. P. McKegney, “Evaluation of patients with advanced cancer using the Karnofsky performance status,” Cancer, vol. 45, no. 8, pp. 2220–2224, 1980. View at Google Scholar · View at Scopus
  30. P. Economopoulou, V. G. Kaklamani, and K. Siziopikou, “The role of cancer stem cells in breast cancer initiation and progression: potential cancer stem cell-directed therapies,” The Oncologist, vol. 17, pp. 1394–1401, 2012. View at Google Scholar
  31. D. Krex, B. Klink, C. Hartmann et al., “Long-term survival with glioblastoma multiforme,” Brain, vol. 130, no. 10, pp. 2596–2606, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Henriksson, T. Asklund, and H. S. Poulsen, “Impact of therapy on quality of life, neurocognitive function and their correlates in glioblastoma multiforme: a review,” Journal of Neuro-Oncology, vol. 104, no. 3, pp. 639–646, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. M. M. Mrugala, “Advances and challenges in the treatment of glioblastoma: a clinician's perspective,” Discovery Medicine, vol. 15, pp. 221–230, 2013. View at Google Scholar
  34. C.-I. Lin, E. E. Whang, D. B. Donner et al., “Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through met inhibition in papillary thyroid cancer,” Molecular Cancer Research, vol. 8, no. 9, pp. 1217–1226, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. Y. J. Song, S. S. Zhang, X. L. Guo et al., “Autophagy contributes to the survival of CD133+ liver cancer stem cells in the hypoxic and nutrient-deprived tumor microenvironment,” Cancer Letters, vol. 339, pp. 70–81, 2013. View at Google Scholar
  36. W. Zhuang, B. Li, L. Long, L. Chen, Q. Huang, and Z. Liang, “Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity,” International Journal of Cancer, vol. 129, no. 11, pp. 2720–2731, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. G. E. Mortimore and C. M. Schworer, “Induction of autophagy by amino-acid deprivation in perfused rat liver,” Nature, vol. 270, no. 5633, pp. 174–176, 1977. View at Google Scholar · View at Scopus
  38. N. Mizushima and D. J. Klionsky, “Protein turnover via autophagy: implications for metabolism,” Annual Review of Nutrition, vol. 27, pp. 19–40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Boya, R.-A. González-Polo, N. Casares et al., “Inhibition of macroautophagy triggers apoptosis,” Molecular and Cellular Biology, vol. 25, no. 3, pp. 1025–1040, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. J. J. Lum, D. E. Bauer, M. Kong et al., “Growth factor regulation of autophagy and cell survival in the absence of apoptosis,” Cell, vol. 120, no. 2, pp. 237–248, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. J. Li, N. Hou, A. Faried, S. Tsutsumi, and H. Kuwano, “Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model,” European Journal of Cancer, vol. 46, no. 10, pp. 1900–1909, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. D. Liu, Y. Yang, Q. Liu, and J. Wang, “Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells,” Medical Oncology, vol. 28, no. 1, pp. 105–111, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. T. S. Zhu, M. A. Costello, C. E. Talsma et al., “Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells,” Cancer Research, vol. 71, no. 18, pp. 6061–6072, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. J.-W. Gu, P. Rizzo, A. Pannuti, T. Golde, B. Osborne, and L. Miele, “Notch signals in the endothelium and cancer, “stem-like” cells: opportunities for cancer therapy,” Vascular Cell, vol. 4, article 7, 2012. View at Publisher · View at Google Scholar