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BioMed Research International
Volume 2014 (2014), Article ID 724209, 7 pages
Research Article

The Clinicopathological Significance of MicroRNA-155 in Breast Cancer: A Meta-Analysis

1Zhongnan Hospital of Wuhan University, Wuhan 430071, China
2Cancer Genomics Branch, National Cancer Center, Goyang-si, Gyeonggi-do 410-769, Republic of Korea
3Hubei University of Chinese Medicine, Wuhan 430061, China

Received 15 May 2014; Accepted 3 July 2014; Published 3 August 2014

Academic Editor: Elisa Giovannetti

Copyright © 2014 Hui Zeng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Previous studies demonstrated that the associations between expression level of microRNA-155 (miR-155) and clinicopathological significance of breast cancer remained inconsistent. Therefore, we performed a meta-analysis based on eligible studies to summarize the possible associations. Methods. We identified eligible studies published up to May 2014 by a comprehensive search of PubMed, EMBASE, CNKI, and VIP databases. The analysis was performed with RevMan. 5.0 software. Results. A total of 15 studies were included. The results of meta-analysis showed that miR-155 was positively correlated with breast cancer with standardized mean difference (SMD) = 1.22. Elevated miR-155 was found in Her-2 positive or lymph node metastasis positive, or p53 mutant type breast cancer. But the result showed to be insignificant in TNM comparison. With respect to estrogen receptor alpha (ER) and progesterone receptor (PR) status, both of them showed significant associations with SMD = −1.2 and −1.85, respectively. Conclusion. MiR-155 detection might have a diagnostic value in breast cancer patients. It might be used as an auxiliary biomarker for different clinicopathological breast cancer.