BioMed Research International

MicroRNAs in Cancer Management: Big Challenges for Small Molecules


Publishing date
24 Oct 2014
Status
Published
Submission deadline
06 Jun 2014

1Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, 20133 Milan, Italy

2Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

3Center for Genomic Science of IIT@SEMM at the Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milan, Italy


MicroRNAs in Cancer Management: Big Challenges for Small Molecules

Description

In the last decade, increasing attention has been devoted to the study of microRNAs (miRNAs), 22 nt long RNAs able to exert a negative posttranscriptional regulation on cohorts of target mRNAs, thus playing a role as master regulators of entire biological processes. In the cancer field, investigation led to the identification of miRNAs as potential biomarkers for tumor diagnosis and prediction of patient’s prognosis or response to treatment. In addition, a number of miRNAs have been shown to directly participate to tumorigenesis by acting as “oncoMirs” or “tumor suppressive miRNAs,” thus becoming potential key targets or tools for anticancer therapy. However, a number of technical issues still need to be solved before miRNAs may actually enter the clinical armamentarium as either markers or therapeutic agents. In particular, our knowledge about the mechanisms of miRNA function and expression regulation is still fragmentary when compared to what is needed for the development of reliable and safe miRNA-based clinical strategies. This issue is intended to provide evidence of the potential usefulness of miRNAs in cancer management as well as focus on the still unsolved technical and conceptual challenges in miRNA research. Potential topics include, but are not limited to:

  • MiRNAs as markers for cancer detection, risk assessment, and prediction of therapy response
  • MiRNAs as oncogenes or tumor suppressors: relevance in cancer development and progression, functional targets
  • MiRNA detection: methods for miRNA isolation and quantification, in situ detection, subcellular localization, miRNA profiling, normalization and identification of endogenous controls, and bioinformatics applied to miRNA research
  • Complexity of miRNA biogenesis: transcription, host genes, processing, posttranscriptional modifications, and miRNA degradation
  • MiRNA target prediction and identification: tools, experimental validation, factors affecting miRNA-target interaction, and ceRNAs
  • MiRNA inhibition/overexpression for functional studies and therapeutic approaches: strategies, off-target effects, in vivo applications, and use of miRNA-based therapies as a “one hit-multitarget approach” for direct antitumor effect or in combination with conventional treatments
  • MiRNA knock-out and knock-in in vivo

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/bmri/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/bmri/genetics/mcbs/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 982156
  • - Editorial

MicroRNAs in Cancer Management: Big Challenges for Small Molecules

Paolo Gandellini | Elisa Giovannetti | Francesco Nicassio
  • Special Issue
  • - Volume 2015
  • - Article ID 374924
  • - Review Article

Utility of MicroRNAs and siRNAs in Cervical Carcinogenesis

Sacnite del Mar Díaz-González | Jessica Deas | ... | Oscar Peralta-Zaragoza
  • Special Issue
  • - Volume 2015
  • - Article ID 125094
  • - Review Article

MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges

Huiyin Lan | Haiqi Lu | ... | Hongchuan Jin
  • Special Issue
  • - Volume 2015
  • - Article ID 731479
  • - Review Article

Challenges in Using Circulating miRNAs as Cancer Biomarkers

Paola Tiberio | Maurizio Callari | ... | Valentina Appierto
  • Special Issue
  • - Volume 2015
  • - Article ID 717509
  • - Review Article

Analysis of Chromosome 17 miRNAs and Their Importance in Medulloblastomas

Sebastian López-Ochoa | Marina Ramírez-García | ... | Francisco Arenas-Huertero
  • Special Issue
  • - Volume 2014
  • - Article ID 146170
  • - Review Article

MicroRNA as New Tools for Prostate Cancer Risk Assessment and Therapeutic Intervention: Results from Clinical Data Set and Patients’ Samples

Alessio Cannistraci | Anna Laura Di Pace | ... | Désirée Bonci
  • Special Issue
  • - Volume 2014
  • - Article ID 756975
  • - Review Article

Therapeutic Use of MicroRNAs in Lung Cancer

Orazio Fortunato | Mattia Boeri | ... | Gabriella Sozzi
  • Special Issue
  • - Volume 2014
  • - Article ID 249393
  • - Review Article

The Role of MicroRNAs in Ovarian Cancer

Yasuto Kinose | Kenjiro Sawada | ... | Tadashi Kimura
  • Special Issue
  • - Volume 2014
  • - Article ID 642916
  • - Review Article

The Potential of MicroRNAs in Personalized Medicine against Cancers

Anne Saumet | Anthony Mathelier | Charles-Henri Lecellier
  • Special Issue
  • - Volume 2014
  • - Article ID 678401
  • - Review Article

Molecular Mechanisms Underlying the Role of MicroRNAs in the Chemoresistance of Pancreatic Cancer

Ingrid Garajová | Tessa Y. Le Large | ... | Elisa Giovannetti
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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