Store-Operated Ca²⁺ Entry Does Not Control Proliferation in Primary Cultures of Human Metastatic Renal Cellular Carcinoma

Figure 6

2-Aminoethoxydiphenyl borate and carboxyamidotriazole block store-operated Ca²⁺ entry in mRCC cells. (a) 2-APB (50 μM, 20 min of pre-incubation) selectively inhibited CPA (10 μM)-induced SOCE, but not intracellular Ca²⁺ mobilization. (b) Statistical analysis of the effect exerted by 2-APB on the peak amplitudes of CPA-induced Ca²⁺ release and Ca²⁺ entry. (c) CAI (10 μM, 20 min of preincubation) reduced both phases of the Ca²⁺ response to CPA (10 μM). (d) Statistical analysis of CAI-dependent inhibition of CPA-elicited Ca²⁺ release and CPA-elicited Ca²⁺ entry. ^∗𝑃<0.05 (Student’s 𝑡 test).

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