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BioMed Research International
Volume 2014 (2014), Article ID 760323, 5 pages
http://dx.doi.org/10.1155/2014/760323
Research Article

The Effect of Dexmedetomidine on Oxidative Stress during Pneumoperitoneum

1Department of Anesthesiology and Critical Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
2Department of Nephrology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
3Department of Hematology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey
4Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey

Received 30 October 2013; Accepted 18 December 2013; Published 8 January 2014

Academic Editor: Engin Erturk

Copyright © 2014 Bahanur Cekic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. This study was intended to investigate the effect of dexmedetomidine on oxidative stress response in pneumoperitoneum established in rats. Methods. Animals were randomized into three groups, group S: with no pneumoperitoneum, group P: with pneumoperitoneum established, and group D: given 100 mcg intraperitoneal dexmedetomidine 30 min before establishment of pneumoperitoneum. Plasma total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) activity were measured 30 min after conclusion of pneumoperitoneum. Results. The mean TOS level was significantly higher in group P than in the other two groups, and the TOS level was significantly higher in group D than in group S (). Plasma TAS level was found to be lower in group P than in the other two groups, and the TAS level was lower in group D than in group S (). Consequently, the OSI was significantly higher in group P than in groups D and S (). Conclusions. Ischemia-reperfusion phenomenon that occurs during pneumoperitoneum causes oxidative stress and consumption of plasma antioxidants. Dexmedetomidine decreases oxidative stress caused by pneumoperitoneum and strengthens the antioxidant defense system.