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BioMed Research International
Volume 2014 (2014), Article ID 839232, 9 pages
http://dx.doi.org/10.1155/2014/839232
Research Article

Proteomic Analysis of Gossypol Induces Necrosis in Multiple Myeloma Cells

1Clinical Laboratory of Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
2Binzhou Medical University, Yantai 264003, China
3Department of Nuclear Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
4School of Life Sciences, Tsinghua University, Beijing 100084, China

Received 5 June 2014; Accepted 20 July 2014; Published 14 August 2014

Academic Editor: Haiteng Deng

Copyright © 2014 Renhua Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1. Gossypol induced the fold of changes in DNA damage repair and replication associated proteins from the untreated and 40 μM gossypol-treated U266 cells for 24 h as determined by quantitative proteomics.

Supplementary Figure 2. Gossypol induced the fold of changes in mitochondrial 28S associated proteins from the untreated and 40 μM gossypol-treated U266 cells for 24 h as determined by quantitative proteomics.

Supplementary Figures 3. Gossypol induced the fold of changes in mitochondrial 39S associated proteins from the untreated and 40 μM gossypol-treated U266 cells for 24 h as determined by quantitative proteomics.

Supplementary Figure 4. The MS/MS spectra of peptides for identification of selected proteins.

Supplementary Table 1. Up-regulated proteins in gossypol-treated cells.

Supplementary Table 2. Down-regulated proteins in gossypol-treated cells.

  1. Supplementary Materials