Therapeutic Effects of PADRE-BAFF Autovaccine on Rat Adjuvant Arthritis

Figure 4

The clinical score of AA model in SD rats. (a) Thirty rats were subcutaneously immunized with PADRE-BAFF at two-week intervals for three times followed by a boost given intraperitoneally (i.p.). AA model was induced when the antibody titer was over 1×10⁵ and scored for clinical signs of RA as described in Section 2. Results are plotted as the mean clinical score ± SEM. The graph shows pooled data from three different experiments (10 rats per group). *𝑃<0.05 compared with normal group. (b) SD rats were immunized with PADRE-BAFF or saline and then AA model was induced and the paw swelling was measured with a caliper. Data are representative of three experiments. *𝑃<0.05, **𝑃<0.01, and ^#𝑃<0.05 compared with normal group.

(a)

(b)