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BioMed Research International
Volume 2014, Article ID 867321, 4 pages
http://dx.doi.org/10.1155/2014/867321
Research Article

LRRK2 G2385R and R1628P Mutations Are Associated with an Increased Risk of Parkinson’s Disease in the Malaysian Population

1Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
2Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
3Department of Neurology, Hospital Pulau Pinang, 10990 Penang, Malaysia
4Division of Neurology, Department of Medicine, Hospital Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
5Division of Neurology, Department of Medicine, Hospital Sultanah Nur Zahirah, 20400 Kuala Terengganu, Malaysia
6Department of Neurology, Hospital Kuala Lumpur, 50586 Kuala Lumpur, Malaysia
7Department of Medicine, Hospital Seberang Jaya, 13700 Penang, Malaysia
8Department of Clinical Research and Neurology, Singapore General Hospital, Singapore 169608

Received 23 May 2014; Accepted 24 July 2014; Published 28 August 2014

Academic Editor: Hiroyuki Tomiyama

Copyright © 2014 Aroma Agape Gopalai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson’s disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certain Asian populations but have not been studied in the Malaysian population. Therefore, we screened the G2385R and R1628P variants in 1,202 Malaysian subjects consisting of 695 cases and 507 controls. The G2385R and R1628P variants were associated with a 2.2-fold () and 1.2-fold () increased risk of PD, respectively. Our data concur with other reported findings in Chinese, Taiwanese, Singaporean, and Korean studies.