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BioMed Research International
Volume 2014, Article ID 869186, 5 pages
http://dx.doi.org/10.1155/2014/869186
Research Article

Breath Ketone Testing: A New Biomarker for Diagnosis and Therapeutic Monitoring of Diabetic Ketosis

1Department of Endocrinology, The Second Hospital of Jilin University, 218 Ziqiang Road, Changchun, Jilin 130041, China
2Research Center of Analytical Instrumentation, Analytical & Testing Center, Sichuan University, 29 Wangjiang Road, Chengdu 610064, China

Received 28 March 2014; Revised 21 April 2014; Accepted 21 April 2014; Published 11 May 2014

Academic Editor: Cheng Hu

Copyright © 2014 Yue Qiao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. Bonadio, “Pediatric diabetic ketoacidosis: an outpatient perspective on evaluation and management,” Pediatric Emergency Medicine Practice, vol. 10, pp. 1–14, 2013. View at Google Scholar
  2. P. Drouin, J. F. Blickle, B. Charbonnel et al., “Diagnosis and classification of diabetes mellitus: the new criteria,” Diabetes and Metabolism, vol. 25, no. 1, pp. 72–83, 1999. View at Google Scholar · View at Scopus
  3. M. G. Zhou, Y. Liu, W. W. Li et al., “Investigation and identification of breath acetone as a potential biomarker for type 2 diabetes diagnosis,” Chinese Science Bulletin, 2014. View at Publisher · View at Google Scholar
  4. D. P. Westerberg, “Diabetic ketoacidosis: evaluation and treatment,” American Family Physician, vol. 87, pp. 337–346, 2013. View at Google Scholar
  5. M. Fritsch, E. Schober, B. Rami-Merhar, S. Hofer, E. Frohlich-Reiterer, and T. Waldhoer, “Diabetic ketoacidosis at diagnosis in Austrian children: a population-based analysis, 1989–2011,” The Journal of Pediatrics, vol. 163, no. 5, pp. 1484–1488, 2013. View at Publisher · View at Google Scholar
  6. G. J. Klingensmith, W. V. Tamborlane, J. Wood et al., “Diabetic ketoacidosis at diabetes onset: still an all too common threat in youth,” The Journal of Pediatrics, vol. 162, no. 2, pp. 330.e1–334.e1, 2013. View at Google Scholar
  7. W. Miekisch, J. K. Schubert, and G. F. E. Noeldge-Schomburg, “Diagnostic potential of breath analysis—focus on volatile organic compounds,” Clinica Chimica Acta, vol. 347, no. 1-2, pp. 25–39, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. C. Turner, P. Spanel, and D. Smith, “A longitudinal study of ammonia, acetone and propanol in the exhaled breath of 30 subjects using selected ion flow tube mass spectrometry, SIFT-MS,” Physiological Measurement, vol. 27, no. 4, pp. 321–337, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. N. Yamane, T. Tsuda, K. Nose, A. Yamamoto, H. Ishiguro, and T. Kondo, “Relationship between skin acetone and blood β-hydroxybutyrate concentrations in diabetes,” Clinica Chimica Acta, vol. 365, no. 1-2, pp. 325–329, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Deng, J. Zhang, X. Yu, W. Zhang, and X. Zhang, “Determination of acetone in human breath by gas chromatography-mass spectrometry and solid-phase microextraction with on-fiber derivatization,” Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 810, no. 2, pp. 269–275, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Zeugswetter and M. Pagitz, “Ketone measurements using dipstick methodology in cats with diabetes mellitus,” Journal of Small Animal Practice, vol. 50, no. 1, pp. 4–8, 2009. View at Publisher · View at Google Scholar · View at Scopus