Glycyrrhizic Acid in the Treatment of Liver Diseases: Literature Review

Table 2

Mechanism of action of glycyrrhizin compound chemotherapy.

Compound	Pharmacological activities	Mechanisms of action	Reference
Glycyrrhizic acid	Anti-inflammatory; antiviral; inhibition of hepatic fibrosis	Regulating the expression of inflammation-related factors; inhibition replication of viral mRNA	[46–49]; [51, 59]; [45]
Compound glycyrrhizin tablet	Improving the liver dysfunction; augmented the entire cytotoxic function mediated by hepatic lymphocytes; inhibiting the cascade leading to apoptosis	Regulating the expression of inflammation-related factors; promoting the growth of hepatocyte; inhibition replication of viral mRNA	[60]; [61]; [62]
Glycyrrhetinic acid	Anti-inflammatory; antiviral; antiallergic; antitumor proliferation	Regulating the expression of inflammation-related factors; inhibition replication of viral; inhibition of the expression of sensitizing factors and tumor-associated factor;	[63]; [64]; [65]; [66]
18𝛽-glycyrrhetic acid	Antiviral; anti-inflammatory	Regulating the expression of inflammation-related factors; inhibition replication of viral mRNA	[67]
Diammonium glycyrrhizinate	Anti-inflammatory, resistance to biologic oxidation and membranous protection; neuroprotective effect	Regulating the expression of inflammation-related factors; regulating the enzymatic reactions’ related oxidation	[68]
Dipotassium glycyrrhizinate	Anti-inflammatory	Regulating the expression of inflammation-related factors	[69]