Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 892704, 6 pages
http://dx.doi.org/10.1155/2014/892704
Research Article

The Effects of Remote Ischemic Preconditioning and N-Acetylcysteine with Remote Ischemic Preconditioning in Rat Hepatic Ischemia Reperfusion Injury Model

1Department of Anesthesiology and Reanimation, Dokuz Eylul University Medical School, Inciralti, 35340 Izmir, Turkey
2Department of Histology and Embryology, University Medical School, 35340 Izmir, Turkey
3Department of Laboratory Animal Science, University Medical School, 35340 Izmir, Turkey
4Department of Biochemistry, University Medical School, 35340 Izmir, Turkey
5Department of Public Health, University Medical School, 35340 Izmir, Turkey

Received 27 August 2013; Accepted 22 November 2013; Published 8 January 2014

Academic Editor: Ahmet Eroglu

Copyright © 2014 Ali Ihsan Uysal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. D. Collard and S. Gelman, “Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury,” Anesthesiology, vol. 94, no. 6, pp. 1133–1138, 2001. View at Google Scholar · View at Scopus
  2. S.-S. Huang, F.-C. Wei, and L.-M. Hung, “Ischemic preconditioning attenuates postischemic leukocyte-endothelial cell interactions—role of nitric oxide and protein kinase C,” Circulation Journal, vol. 70, no. 8, pp. 1070–1075, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. Ç. Olguner, U. Koca, A. Kar et al., “Ischemic preconditioning attenuates the lipid peroxidation and remote lung injury in the rat model of unilateral lower limb ischemia reperfusion,” Acta Anaesthesiologica Scandinavica, vol. 50, no. 2, pp. 150–155, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Gueler, J.-K. Park, S. Rong et al., “Statins attenuate ischemia-reperfusion injury by inducing heme oxygenase-1 in infiltrating macrophages,” American Journal of Pathology, vol. 170, no. 4, pp. 1192–1199, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. P.-A. Clavien, M. Selzner, H. A. Rüdiger et al., “A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning,” Annals of Surgery, vol. 238, no. 6, pp. 843–852, 2003. View at Google Scholar · View at Scopus
  6. D. L. Carden and D. N. Grander, “Pahtophysiology of ischemia-reperfusion injury,” The Journal of Pathology, vol. 190, pp. 255–266, 2000. View at Google Scholar
  7. C. Peralta, N. Prats, C. Xaus, E. Gelpí', and J. Roselló-Catafau, “Protective effect of liver ischemic preconditioning on liver and lung injury induced by hepatic ischemia-reperfusion in the rat,” Hepatology, vol. 30, no. 6, pp. 1481–1489, 1999. View at Google Scholar · View at Scopus
  8. C. Peralta, L. Fernández, J. Panés et al., “Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat,” Hepatology, vol. 33, no. 1, pp. 100–113, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Jaeschke and B. L. Woolbright, “Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species,” Transplantation Reviews, vol. 26, no. 2, pp. 103–114, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Laurikka, Z.-K. Wu, P. Iisalo et al., “Regional ischemic preconditioning enhances myocardial performance in off-pump coronary artery bypass grafting,” Chest, vol. 121, no. 4, pp. 1183–1189, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Takaoka, I. Nakae, K. Mitsunami et al., “Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: effects of ‘remote preconditioning’,” Journal of the American College of Cardiology, vol. 33, no. 2, pp. 556–564, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Bahde and H.-U. Spiegel, “Hepatic ischaemia-reperfusion injury from bench to bedside,” British Journal of Surgery, vol. 97, no. 10, pp. 1461–1475, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Khanna, V. Diwan, M. Singh, N. Singh, and A. S. Jaggi, “Reduction of ischemic, pharmacological and remote preconditioning effects by an antioxidant N-Acetyl Cysteine pretreatment in isolated rat heart,” Yakugaku Zasshi, vol. 128, no. 3, pp. 469–477, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. A. Galhardo, C. Quireze Jr., P. G. R. Navarro, R. J. Morello, M. D. J. Simões, and E. F. D. S. Montero, “Liver and lung late alterations following hepatic reperfusion associated to ischemic preconditioning or N-acetylcysteine,” Microsurgery, vol. 27, no. 4, pp. 295–299, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. J.-C. Orban, J. Levraut, S. Gindre et al., “Effects of acetylcysteine and ischaemic preconditioning on muscular function and postoperative pain after orthopaedic surgery using a pneumatic tourniquet,” European Journal of Anaesthesiology, vol. 23, no. 12, pp. 1025–1030, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. V. Smyrniotis, N. Arkadopoulos, G. Kostopanagiotou et al., “Attenuation of ischemic injury by N-acetylcysteine preconditioning of the liver,” Journal of Surgical Research, vol. 129, no. 1, pp. 31–37, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. A. O. Sehirli, G. Sener, H. Satiroglu, and G. Ayanoǧlu-Dülger, “Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat,” Journal of Nephrology, vol. 16, no. 1, pp. 75–80, 2003. View at Google Scholar · View at Scopus
  18. M. V. Küntscher, T. Kastell, M. Sauerbier, R. Nobiling, M. M. Gebhard, and G. Germann, “Acute remote ischemic preconditioning on a rat cremasteric muscle flap model,” Microsurgery, vol. 22, no. 6, pp. 221–226, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Şahin, Ç. Olguner, H. A. Bodur et al., “Comparison of the effects of the remote and direct ischemic preconditioning in the liver ischemia-reperfusion injury,” Turkiye Klinikleri Journal of Medical Sciences, vol. 29, no. 2, pp. 381–387, 2009. View at Google Scholar · View at Scopus
  20. G. Darilmaz, S. Topaloglu, E. Topaloglu et al., “Evaluation of liver damage after application of TVE in the rat model,” Transplantation Proceedings, vol. 37, no. 10, pp. 4550–4552, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. V. B. Nieuwenhuijs, M. T. D. Bruijn, R. T. A. Padbury, and G. J. Barritt, “Hepatic ischemia-reperfusion injury: roles of Ca2+ and other intracellular mediators of impaired bile flow and hepatocyte damage,” Digestive Diseases and Sciences, vol. 51, no. 6, pp. 1087–1102, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. P.-A. Clavien, S. Yadav, D. Sindram, and R. C. Bentley, “Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans,” Annals of Surgery, vol. 232, no. 2, pp. 155–162, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Kanoria, R. Jalan, N. A. Davies, A. M. Seifalian, R. Williams, and B. R. Davidson, “Remote ischaemic preconditioning of the hind limb reduces experimental liver warm ischaemia-reperfusion injury,” British Journal of Surgery, vol. 93, no. 6, pp. 762–768, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Przyklenk, B. Bauer, M. Ovize, R. A. Kloner, and P. Whittaker, “Regional ischemic “preconditioning” protects remote virgin myocardium from subsequent sustained coronary occlusion,” Circulation, vol. 87, no. 3, pp. 893–899, 1993. View at Google Scholar · View at Scopus
  25. E. Ateş, E. Gency̧, N. Erkasap et al., “Renal protection by brief liver ischemia in rats,” Transplantation, vol. 74, no. 9, pp. 1247–1251, 2002. View at Google Scholar · View at Scopus
  26. Y. Saita, K. Yokoyama, K. Nakamura, and M. Itoman, “Protective effect of ischaemic preconditioning against ischaemia-induced reperfusion injury of skeletal muscle: how many preconditioning cycles are appropriate?” British Journal of Plastic Surgery, vol. 55, no. 3, pp. 241–245, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. J. M. Davis, D. C. Gute, S. Jones, A. Krsmanovic, and R. J. Korthuis, “Ischemic preconditioning prevents postischemic P-selectin expression in the rat small intestine,” American Journal of Physiology: Heart and Circulatory Physiology, vol. 277, no. 6, pp. H2476–H2481, 1999. View at Google Scholar · View at Scopus
  28. I.-R. Lai, K.-J. Chang, C.-F. Chen, and H.-W. Tsai, “Transient limb ischemia induces remote preconditioning in liver among rats: the protective role of heme oxygenase-1,” Transplantation, vol. 81, no. 9, pp. 1311–1317, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Abu-Amara, S. Y. Yang, A. Quaglia et al., “Role of endothelial nitric oxide synthase in remote ischemic preconditioning of the mouse liver,” Liver Transplantation, vol. 17, no. 5, pp. 610–619, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. S. Ghosh, J. Baumann, B. Falusi, L. Bogár, E. Roth, and J. Gál, “Hemodynamic effects of N-acetylcystein and ischemic preconditioning in a liver ischemia-reperfusion model,” Orvosi Hetilap, vol. 149, no. 47, pp. 2245–2249, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Baumann, S. Ghosh, T. Szakmany et al., “Short-term effects of N-acetylcysteine and ischemic preconditioning in a canine model of hepatic ischemia-reperfusion injury,” European Surgical Research, vol. 41, no. 2, pp. 226–230, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Kanoria, G. Glantzounis, A. Quaglia et al., “Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injury,” Transplant International, vol. 25, no. 7, pp. 783–791, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. F. Wang, S. E. Birch, R. He et al., “Remote ischemic preconditioning by hindlimb occlusion prevents liver ischemic/reperfusion injury: the role of high mobility group-box 1,” Annals of Surgery, vol. 251, no. 2, pp. 292–299, 2010. View at Publisher · View at Google Scholar · View at Scopus