Cytotoxicity of Portuguese Propolis: The Proximity of the In Vitro Doses for Tumor and Normal Cell Lines

Table 2

Correlations established between content in phenolics and flavonoids (mg/g of extract) and cytotoxicity GI₅₀ values (𝜇g/mL) of phenolic extracts from Portuguese propolis of different origins.

	MCF7	NCI-H460	HCT15	HeLa	HepG2	PLP2
Phenolic acids	𝑦=−6.9987𝑥+333.66; 𝑅^2=0.4883	𝑦=−4.7627𝑥+204.52; 𝑅^2=0.9454	𝑦=−1.1696𝑥+86.11; 𝑅^2=0.5367	𝑦=−2.1202𝑥+156.37; 𝑅^2=0.5928	𝑦=−4.1673𝑥+209.11; 𝑅^2=0.7655	𝑦=−1.7531𝑥+133.46; 𝑅^2=0.7442
Phenolic esters	𝑦=−3.3612𝑥+259.49; 𝑅^2=0.034	𝑦=−6.0297𝑥+306.39; 𝑅^2=0.4579	𝑦=−1.882𝑥+163.43; 𝑅^2=0.4201	𝑦=−3.4135𝑥+276.56; 𝑅^2=0.4643	𝑦=−4.9099𝑥+299.63; 𝑅^2=0.3211	𝑦=−2.4935𝑥+226.99; 𝑅^2=0.4549
Total phenolics	𝑦=−10.36𝑥+593.15; 𝑅^2=0.1521	𝑦=−10.792𝑥+510.91; 𝑅^2=0.6900	𝑦=−3.052𝑥+249.54; 𝑅^2=0.5195	𝑦=−5.5337𝑥+432.93; 𝑅^2=0.5740	𝑦=−9.0772𝑥+508.74; 𝑅^2=0.5163	𝑦=−4.2466𝑥+360.45; 𝑅^2=0.6207
Flavonols	𝑦=0.0481𝑥+87.45; 𝑅^2=0.0001	𝑦=0.3793𝑥+77.724; 𝑅^2=0.0092	𝑦=0.4697𝑥+78.163; 𝑅^2=0.1837	𝑦=0.2617𝑥+76.058; 𝑅^2=0.0587	𝑦=1.1011𝑥+51.202; 𝑅^2=0.0471	𝑦=0.9117𝑥+53.017; 𝑅^2=0.1874
Flavones	𝑦=−0.3895𝑥+82.467; 𝑅^2=0.4736	𝑦=−0.4097𝑥+79.497; 𝑅^2=0.4786	𝑦=−0.591𝑥+81.208; 𝑅^2=0.5913	𝑦=−0.4634𝑥+91.432; 𝑅^2=0.6394	𝑦=−0.4459𝑥+81.911; 𝑅^2=0.4314	𝑦=−0.3797𝑥+81.606; 𝑅^2=0.4507
Dihydroflavonols	𝑦=−2.1673𝑥+109.73; 𝑅^2=0.4027	𝑦=−1.2445𝑥+61.239; 𝑅^2=0.1981	𝑦=−0.196𝑥+27.711; 𝑅^2=0.0645	𝑦=−0.3877𝑥+42.748; 𝑅^2=0.2585	𝑦=0.0286𝑥+22.028; 𝑅^2=0.0006	𝑦=0.458𝑥+10.091; 𝑅^2=0.1726
Flavanones	𝑦=2.4455𝑥−29.308; 𝑅^2=0.0469	𝑦=1.0683𝑥+33.159; 𝑅^2=0.0374	𝑦=1.3164𝑥+41.508; 𝑅^2=0.5347	𝑦=2.0971𝑥−25.231; 𝑅^2=0.4561	𝑦=1.719𝑥+5.1786; 𝑅^2=0.1024	𝑦=1.4251𝑥+9.3367; 𝑅^2=0.3868
Flavonoid esters	𝑦=−1.6488𝑥+167.17; 𝑅^2=0.0079	𝑦=−2.4757𝑥+176.14; 𝑅^2=0.0745	𝑦=1.1061𝑥+84.981; 𝑅^2=0.1401	𝑦=1.6454𝑥+33.882; 𝑅^2=0.1042	𝑦=−0.4261𝑥+118.74; 𝑅^2=0.0023	𝑦=0.5517𝑥+82.834; 𝑅^2=0.0215
Total flavonoids	𝑦=−2.2𝑥+403.65; 𝑅^2=0.5071	𝑦=−2.3009𝑥+386.17; 𝑅^2=0.5066	𝑦=−3.05𝑥+383.97; 𝑅^2=0.5191	𝑦=−2.4582𝑥+442.68; 𝑅^2=0.6038	𝑦=−2.5236𝑥+400.76; 𝑅^2=0.4636	𝑦=−2.0844𝑥+395.37; 𝑅^2=0.4529