Artificial Extracellular Matrices with Oversulfated Glycosaminoglycan Derivatives Promote the Differentiation of Osteoblast-Precursor Cells and Premature Osteoblasts

Table 1

Characteristics of the GAG derivatives.

Sample		DSS^a	MW^b; [g/mol]	PD^c
sCS1	Chondroitin sulfate	1	17,900	1.4
sCS2	Sulfated chondroitin sulfate	2	23,200	1.5
sCS3	Sulfated chondroitin sulfate	3	19,900	1.5
HA	Hyaluronan	0	1,17 × 10^6	4.8
sHA1Δ4S	Sulfated hyaluronan	1	26,400	2.0
sHA1Δ6S	Sulfated hyaluronan	1	42,600	2.0
sHA2	Sulfated hyaluronan	2	26,400	1.8
sHA3	Sulfated hyaluronan	3	47,800	1.7

^aDS_S: degree of sulfation (average number of sulfate groups per disaccharide repeating unit).
^bM_W: weight-average molecular weight determined by gel permeation chromatography (GPC) using laser light scattering (LLS) detection.
^cPD: polydispersity index, determined from the molecular weight distribution calculated from the number-average and weight average molecular weights obtained by GPC with refraction index (RI) detection.