Muscle-Type Specific Autophosphorylation of CaMKII Isoforms after Paced Contractions

Table 1

Relative influences of the model input parameters on the transient in phosphoThr287-CaMKII.

Parameter	Relative influence
kbta	0.32
kPP1	0.24
CaMax	0.22
KmPP1	0.20
CaPump	0.11
kbi	0.06
kbtc	0.06
kTrop1	0.04
kMitCa2	0.04
kDye2	0.03
kMitCa1	0.03
kATP2	0.03
kCaM42	0.03
kParvCa1	0.03
kParvCa2	0.03
kMitMg1	0.03
kDye1	0.03
kATP1	0.03
kbtb	0.03
kCSQN1	0.02
kCaM0Boff	0.02
KdPump	0.02
kMitMg2	0.02
kCaM20	0.02
kTrop2	0.02
kCSQN2	0.02
kParvMg1	0.02
kParvMg2	0.02

Values were calculated as described under multiparametric sensitivity analysis in Section 2.6 “Model Development” of the “Materials and Methods” section. A higher value indicates a larger influence. The most influential parameters are the speed of auto- and dephosphorylation (i.e, kbta, kPPi) and the activity of the calcium pumps (i.e, CaMax, CaPump). For abbreviations consult Tables 2 and 3.