Frequency and Clinical Implication of the R450H Mutation in the Thyrotropin Receptor Gene in the Japanese Population Detected by Smart Amplification Process 2

Table 3

Thyroid function and antithyroid antibodies in carriers of the R450H mutation in TSHR.

Test day	Case  1	Case  2				Reference range
	April 2008	March 2008	April 2009	May 2009	June 2010
Age (years)	77	71
Gender	Man	Man
Disease	Type 2 DM	Hypertension
BMI (kg/m^2)	23.4	24.6
TSH (𝜇U/mL)	2.61	3.68	6.87	4.13	5.37	0.35–4.94
FT3 (pg/mL)	3.10	3.00	2.40	2.51	2.57	1.71–3.71
FT4 (ng/dL)	1.08	1.22	0.96	1.11	1.10	0.70–1.48
TgAb (IU/mL)	11.3	17.9				<28
TPOAb (IU/mL)	<5.0	<5.0				<16

Type 2 DM: type 2 diabetes mellitus.