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BioMed Research International
Volume 2015, Article ID 104132, 6 pages
http://dx.doi.org/10.1155/2015/104132
Review Article

Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

Washington University School of Medicine, St. Louis, MO 63110, USA

Received 5 November 2014; Accepted 27 January 2015

Academic Editor: Federico Salomone

Copyright © 2015 Brian N. Finck and Angela M. Hall. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [23 citations]

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  • M. K. Montgomery, C. E. Fiveash, J. P. Braude, B. Osborne, S. H. J. Brown, T. W. Mitchell, and N. Turner, “Disparate metabolic response to fructose feeding between different mouse strains,” Scientific Reports, vol. 5, pp. 18474, 2015. View at Publisher · View at Google Scholar
  • Xiao-Yu Guo, Jian Liu, and Yu Gao, “Nonalcoholic fatty liver disease: Pathogenesis and incretin based therapies,” World Chinese Journal of Digestology, vol. 23, no. 31, pp. 4990–4996, 2015. View at Publisher · View at Google Scholar
  • Aritz Lopategi, Cristina López-Vicario, José Alcaraz-Quiles, Verónica García-Alonso, Bibiana Rius, Esther Titos, and Joan Clària, “Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction,” Molecular and Cellular Endocrinology, 2015. View at Publisher · View at Google Scholar
  • Wensheng Liu, Robert D. Baker, Tavleen Bhatia, Lixin Zhu, and Susan S. Baker, “Pathogenesis of nonalcoholic steatohepatitis,” Cellular and Molecular Life Sciences, 2016. View at Publisher · View at Google Scholar
  • Jina Kim, Yu-Jin Lee, Jung Min Kim, Dong Cho Han, So Young Lee, Myung-Ae Bae, Jin Hee Ahn, and Byoung-Mog Kwon, “PPARγ agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARγ phosphatase,” International Journal of Biochemistry and Cell Biology, vol. 81, pp. 57–66, 2016. View at Publisher · View at Google Scholar
  • Peter J. Meikle, and Scott A. Summers, “Sphingolipids and phospholipids in insulin resistance and related metabolic disorders,” Nature Reviews Endocrinology, 2016. View at Publisher · View at Google Scholar
  • Kasper W. ter Horst, Pim W. Gilijamse, Ruth I. Versteeg, Mariette T. Ackermans, Aart J. Nederveen, Susanne E. la Fleur, Johannes A. Romijn, Max Nieuwdorp, Dongyan Zhang, Varman T. Samuel, Daniel F. Vatner, Kitt F. Petersen, Gerald I. Shulman, and Mireille J. Serlie, “Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans,” Cell Reports, vol. 19, no. 10, pp. 1997–2004, 2017. View at Publisher · View at Google Scholar
  • Max C. Petersen, and Gerald I. Shulman, “Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance,” Trends in Pharmacological Sciences, 2017. View at Publisher · View at Google Scholar
  • Xiaolu Wang, Yun Gao, Juan Song, Chao Tang, Man Wang, Linli Que, Li Liu, Guoqing Zhu, Qi Chen, Yong Yao, Yong Xu, Jiantao Li, and Yuehua Li, “The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation,” British Journal of Pharmacology, 2017. View at Publisher · View at Google Scholar
  • G. Craig Wood, Xin Chu, George Argyropoulos, Peter Benotti, David Rolston, Tooraj Mirshahi, Anthony Petrick, John Gabrielson, David J. Carey, Johanna K. DiStefano, Christopher D. Still, and Glenn S. Gerhard, “A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains,” Scientific Reports, vol. 7, pp. 43238, 2017. View at Publisher · View at Google Scholar
  • Oliver Hahn, Sebastian Grönke, Thomas M. Stubbs, Gabriella Ficz, Oliver Hendrich, Felix Krueger, Simon Andrews, Qifeng Zhang, Michael J. Wakelam, Andreas Beyer, Wolf Reik, and Linda Partridge, “Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism,” Genome Biology, vol. 18, no. 1, 2017. View at Publisher · View at Google Scholar
  • Magdalene K. Montgomery, Simon H. J. Brown, Todd W. Mitchell, Adelle C. F. Coster, Gregory J. Cooney, and Nigel Turner, “Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains,” Scientific Reports, vol. 7, no. 1, 2017. View at Publisher · View at Google Scholar
  • Qin Yang, Archana Vijayakumar, and Barbara B. Kahn, “Metabolites as regulators of insulin sensitivity and metabolism,” Nature Reviews Molecular Cell Biology, 2018. View at Publisher · View at Google Scholar
  • Jared A. Gatto, Jill L. Fink, Michael R. Brent, Thomas J. Baranski, Laura Palanker Musselman, and Ezekiel J. Maier, “Seven-up is a novel regulator of insulin signaling,” Genetics, vol. 208, no. 4, pp. 1643–1656, 2018. View at Publisher · View at Google Scholar
  • Thomas Laeger, Teresa Castaño-Martinez, Martin W. Werno, Lukasz Japtok, Christian Baumeier, Wenke Jonas, Burkhard Kleuser, and Annette Schürmann, “Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes,” Diabetologia, 2018. View at Publisher · View at Google Scholar
  • Habib Yaribeygi, Stephen L. Atkin, Majid Ramezani, and Amirhossein Sahebkar, “A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction,” Journal of Cellular Physiology, 2018. View at Publisher · View at Google Scholar
  • Yang Wang, Gilles Fouret, Beatrice Bonafos, Agnieszka Blachnio-Zabielska, Thibault Leroy, David Crouzier, Bruno Barea, Sylvie Gaillet, Cedric Moro, Jerome Lecomte, Charles Coudray, and Christine Feillet-Coudray, “Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats,” The Journal of Nutritional Biochemistry, 2018. View at Publisher · View at Google Scholar
  • Marta Ramon-Krauel, Thais Pentinat, Vincent W. Bloks, Judith Cebrià, Silvia Ribo, Ricky Pérez-Wienese, Maria Vilà, Ivonne Palacios-Marin, Antonio Fernández-Pérez, Mario Vallejo, Noèlia Téllez, Miguel Àngel Rodríguez, Oscar Yanes, Carles Lerin, Rubén Díaz, Torsten Plosch, Uwe J. F. Tietge, and Josep C. Jimenez-Chillaron, “ Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance ,” The FASEB Journal, vol. 32, no. 11, pp. 6025–6037, 2018. View at Publisher · View at Google Scholar
  • Max C. Petersen, and Gerald I. Shulman, “Mechanisms of Insulin Action and Insulin Resistance,” Physiological Reviews, vol. 98, no. 4, pp. 2133–2223, 2018. View at Publisher · View at Google Scholar
  • Rosaura Rodicio, and Jürgen J. Heinisch, “Protein kinase C in fungi-more than just cell wall integrity,” FEMS Microbiology Reviews, vol. 42, no. 1, pp. 22–39, 2018. View at Publisher · View at Google Scholar
  • Haihong Chen, Qixing Nie, Jielun Hu, Xiaojun Huang, Ke Zhang, Shijie Pan, and Shaoping Nie, “Hypoglycemic and Hypolipidemic Effects of Glucomannan Extracted from Konjac on Type 2 Diabetic Rats,” Journal of Agricultural and Food Chemistry, 2019. View at Publisher · View at Google Scholar
  • Christine Feillet-Coudray, Gilles Fouret, Claire Vigor, Béatrice Bonafos, Bernard Jover, Agnieszka Blachnio-Zabielska, Jennifer Rieusset, François Casas, Sylvie Gaillet, Jean Francois Landrier, Thierry Durand, and Charles Coudray, “Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High-Fat/High-Fructose Diet,” Lipids, 2019. View at Publisher · View at Google Scholar
  • Anne-Sofie Graae, Niels Grarup, Rasmus Ribel-Madsen, Sara H. Lystbæk, Trine Boesgaard, Harald Staiger, Andreas Fritsche, Niels Wellner, Karolina Sulek, Mads Kjolby, Marie Balslev Backe, Sabina Chubanava, Clara Prats, Annette K. Serup, Jesper B. Birk, Johanne Dubail, Linn Gillberg, Sara G. Vienberg, Anders Nykjær, Bente Kiens, Jørgen F.P. Wojtaszewski, Steen Larsen, Suneel S. Apte, Hans-Ulrich Häring, Allan Vaag, Björn Zethelius, Oluf Pedersen, Jonas T. Treebak, Torben Hansen, and Birgitte Holst, “ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations,” Diabetes, vol. 68, no. 3, pp. 502–514, 2019. View at Publisher · View at Google Scholar