BioMed Research International

Non-Alcoholic Steatohepatitis: Pathogenesis and Clinical Management


Status
Published

1Santa Marta e Santa Venera Hospital of Acireale, Catania, Italy

2Tel Aviv Medical Center, Tel-Aviv, Israel

3University of Catania, Catania, Italy

4Washington University School of Medicine, Saint Louis, USA


Non-Alcoholic Steatohepatitis: Pathogenesis and Clinical Management

Description

Nonalcoholic fatty liver disease (NAFLD) is defined as the increase of intrahepatic triglyceride content in the absence of alcohol abuse. NAFLD has become the most prevalent liver disorder in industrialized countries; liver damage may range from simple fatty liver to nonalcoholic steatohepatitis (NASH) which is associated with increased liver-related mortality due to cirrhotic and tumorigenic evolution. It is estimated that NASH is going to be the leading cause for liver transplantation in western countries in the next few years. Apart from liver morbidity, patients with NASH are also at increased risk for cardiovascular morbidity and mortality, although the molecular determinants of this association remain to be identified; however, NASH is emerging not merely as a marker of metabolic impairment but appears to be actively involved in endothelial dysfunction, atherogenesis, and a prothrombotic tendency. Thus, identifying people who have NASH rather than simple fatty liver is of upmost importance; this has led to the development of several noninvasive tools for the assessment of NASH and fibrosis, although there is still a need to find more accurate and cheaper tests and methods. A further challenge for the clinician involved in the management of the patients with NASH is treatment. Not all patients are compliant with lifestyle modifications and several pharmacological treatments have been proposed so far; however, many treatments have been reported to have limited efficacy and safety.

We invite both basic and clinical investigators to contribute original research articles as well as review articles that will help in understanding the pathogenesis and the clinical management of NASH.

Potential topics include, but are not limited to:

  • Incidence and prevalence of fatty liver and NASH
  • Pathogenesis: molecular pathways involved in steatogenesis and fibrogenesis
  • Metabolic consequences of NASH, with special emphasis on the role of gut-liver axis and liver-adipose tissue crosstalk
  • Cardiovascular dysfunction in patients of NASH, with special emphasis on the role of the liver in glucose and lipid homeostasis
  • Lifestyle modifications for the treatment of NASH, including dietary aspects and physical activity approaches
  • Pharmacological treatments, including antioxidants, insulin sensitizing agents, novel drugs, and bariatric surgery

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 153276
  • - Editorial

Non-Alcoholic Steatohepatitis: Pathogenesis and Clinical Management

Federico Salomone | Shira Zelber-Sagi | ... | Elisa Fabbrini
  • Special Issue
  • - Volume 2015
  • - Article ID 460190
  • - Review Article

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

Paola Dongiovanni | Stefano Romeo | Luca Valenti
  • Special Issue
  • - Volume 2015
  • - Article ID 850246
  • - Research Article

Nonalcoholic Steatohepatitis: Involvement of the Telomerase and Proinflammatory Mediators

Rim Serhal | George Hilal | ... | Nada Alaaeddine
  • Special Issue
  • - Volume 2015
  • - Article ID 213737
  • - Review Article

Association of Nonalcoholic Fatty Liver Disease with Subclinical Cardiovascular Changes: A Systematic Review and Meta-Analysis

Enea Bonci | Claudio Chiesa | ... | Lucia Pacifico
  • Special Issue
  • - Volume 2015
  • - Article ID 457473
  • - Clinical Study

Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children

Imeke Goldschmidt | André Di Nanni | ... | Ulrich Baumann
  • Special Issue
  • - Volume 2015
  • - Article ID 895961
  • - Research Article

Fructose-Drinking Water Induced Nonalcoholic Fatty Liver Disease and Ultrastructural Alteration of Hepatocyte Mitochondria in Male Wistar Rat

Norshalizah Mamikutty | Zar Chi Thent | Farihah Haji Suhaimi
  • Special Issue
  • - Volume 2015
  • - Article ID 287401
  • - Review Article

The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease

Alexandra Feldman | Elmar Aigner | ... | Katharina Paulmichl
  • Special Issue
  • - Volume 2015
  • - Article ID 104132
  • - Review Article

Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

Brian N. Finck | Angela M. Hall
  • Special Issue
  • - Volume 2015
  • - Article ID 168905
  • - Review Article

Drug Induced Steatohepatitis: An Uncommon Culprit of a Common Disease

Liane Rabinowich | Oren Shibolet
BioMed Research International
 Journal metrics
Acceptance rate31%
Submission to final decision67 days
Acceptance to publication30 days
CiteScore3.600
Impact Factor2.276
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