BioMed Research International / 2015 / Article / Tab 2

Corrigendum

Corrigendum to “Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy”

Table 2

Parameter estimates of the base and final population PK models (empirical and semiphysiological) for cefazolin.

Description Parameter UnitEstimates (RSE %)
Base modelEmpirical model
CL~GAa
Semiphysiological
model CL~CrCLb

Structural model
 ClearanceL/min0.49 (7)0.119 (58)0.142 (44)
 Central volume L32.5 (16)33.1 (17)14.1 (25)
 Peripheral volume L12.8 (25)12.8 (27)17.1 (7)
 Intercompartmental clearanceL/min0.335 (21)0.326 (25)0.436 (10)
 Free fraction0.289 (5)0.286 (5)0.291 (9)
 Gestation effect on clearance0.217 (16)0.212 (38)
Between-subject variability
 ClearanceCV%22.1 (25)19.9 (24)10.4 (70)
 Central volume CV%49.1 (22)47.6 (21)101.5 (21)
 Peripheral volumeCV%32.7 (41)34.2 (41)68 (26)
 Free fractionCV%18.9 (36)17.5 (37)19.1 (38)
Residual unexplained variability variances
 Proportional, free concentration 0.0162 (8)0.0158 (11)0.0153 (8)
 Additive, free concentration0.176 (34)0.229 (42)0.217 (36)
 Proportional, total concentration0.0348 (8)0.0328 (10)0.0328 (9)
 Additive, total concentration0.662 (48)0.842 (46)0.681 (25)

RSE: relative standard error; GA: gestational age (weeks).
aEmpirical model: .
bSemiphysiological model: .

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