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BioMed Research International
Volume 2015, Article ID 185736, 9 pages
http://dx.doi.org/10.1155/2015/185736
Research Article

Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB

Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, 35131 Padova, Italy

Received 27 May 2015; Accepted 6 August 2015

Academic Editor: Sung-Hoon Kim

Copyright © 2015 Cristina Girardi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Pinna, “Protein kinase CK2: A challenge to canons,” Journal of Cell Science, vol. 115, part 20, pp. 3873–3878, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. N. A. St-Denis and D. W. Litchfield, “From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival,” Cellular and Molecular Life Sciences, vol. 66, no. 11-12, pp. 1817–1829, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. J. H. Trembley, G. Wang, G. Unger, J. Slaton, and K. Ahmed, “CK2: a key player in cancer biology,” Cellular and Molecular Life Sciences, vol. 66, no. 11-12, pp. 1858–1867, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Ruzzene and L. A. Pinna, “Addiction to protein kinase CK2: a common denominator of diverse cancer cells?” Biochimica et Biophysica Acta, vol. 1804, no. 3, pp. 499–504, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Sarno, E. Papinutto, C. Franchin et al., “ATP site-directed inhibitors of protein kinase CK2: an update,” Current Topics in Medicinal Chemistry, vol. 11, no. 11, pp. 1340–1351, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. G. Cozza, L. A. Pinna, and S. Moro, “Kinase CK2 inhibition: an update,” Current Medicinal Chemistry, vol. 20, no. 5, pp. 671–693, 2013. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Siddiqui-Jain, D. Drygin, N. Streiner et al., “CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy,” Cancer Research, vol. 70, no. 24, pp. 10288–10298, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Pierre, P. C. Chua, S. E. Obrien et al., “Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8- carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer,” Journal of Medicinal Chemistry, vol. 54, no. 2, pp. 635–654, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. H. J. Chon, K. J. Bae, Y. Lee, and J. Kim, “The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies,” Frontiers in Pharmacology, vol. 6, article 70, 2015. View at Publisher · View at Google Scholar
  10. R. Battistutta, G. Cozza, F. Pierre et al., “Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer,” Biochemistry, vol. 50, no. 39, pp. 8478–8488, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Zanin, C. Borgo, C. Girardi et al., “Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells,” PLoS ONE, vol. 7, no. 11, Article ID e49193, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Cozza, C. Girardi, A. Ranchio et al., “Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential,” Cellular and Molecular Life Sciences, vol. 71, no. 16, pp. 3173–3185, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Cozza, S. Sarno, M. Ruzzene et al., “Exploiting the repertoire of CK2 inhibitors to target DYRK and PIM kinases,” Biochimica et Biophysica Acta—Proteins and Proteomics, vol. 1834, no. 7, pp. 1402–1409, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Girardi, P. James, S. Zanin, L. A. Pinna, and M. Ruzzene, “Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions,” Biochimica et Biophysica Acta—Molecular Cell Research, vol. 1843, no. 9, pp. 1865–1874, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Di Maira, F. Brustolon, L. A. Pinna, and M. Ruzzene, “Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells,” Cellular and Molecular Life Sciences, vol. 66, no. 20, pp. 3363–3373, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Ruzzene, G. Di Maira, K. Tosoni, and L. A. Pinna, “Assessment of CK2 constitutive activity in cancer cells,” Methods in Enzymology, vol. 484, pp. 495–514, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Pampaloni, R. Richa, and N. Ansari, “Live spheroid formation recorded with light sheet-based fluorescence microscopy,” Methods in Molecular Biology, vol. 1251, pp. 43–57, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Di Maira, M. Salvi, G. Arrigoni et al., “Protein kinase CK2 phosphorylates and upregulates Akt/PKB,” Cell Death and Differentiation, vol. 12, no. 6, pp. 668–677, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Kim and S. H. Kim, “CK2 inhibitor CX-4945 blocks TGF-β1-induced epithelial-to-mesenchymal transition in A549 human lung adenocarcinoma cells,” PLoS ONE, vol. 8, no. 9, Article ID e74342, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Zheng, B. C. McFarland, D. Drygin et al., “Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma,” Clinical Cancer Research, vol. 19, no. 23, pp. 6484–6494, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. M. J. Ku, J. W. Park, B. J. Ryu, Y.-J. Son, S. H. Kim, and S. Y. Lee, “CK2 inhibitor CX4945 induces sequential inactivation of proteins in the signaling pathways related with cell migration and suppresses metastasis of A549 human lung cancer cells,” Bioorganic and Medicinal Chemistry Letters, vol. 23, no. 20, pp. 5609–5613, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Blanco-Aparicio and A. Carnero, “Pim kinases in cancer: diagnostic, prognostic and treatment opportunities,” Biochemical Pharmacology, vol. 85, no. 5, pp. 629–643, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Schwind, N. Wilhelm, S. Kartarius, M. Montenarh, E. Gorjup, and C. Götz, “Protein kinase CK2 is necessary for the adipogenic differentiation of human mesenchymal stem cells,” Biochimica et Biophysica Acta, vol. 1853, no. 10, pp. 2207–2216, 2015. View at Publisher · View at Google Scholar
  24. J. H. Trembley, Z. Chen, G. Unger et al., “Emergence of protein kinase CK2 as a key target in cancer therapy,” BioFactors, vol. 36, no. 3, pp. 187–195, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Dominguez, G. E. Sonenshein, and D. C. Seldin, “Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer,” Cellular and Molecular Life Sciences, vol. 66, no. 11-12, pp. 1850–1857, 2009. View at Google Scholar
  26. S. E. Perea, O. Reyes, I. Baladron et al., “CIGB-300, a novel proapoptotic peptide that impairs the CK2 phosphorylation and exhibits anticancer properties both in vitro and in vivo,” Molecular and Cellular Biochemistry, vol. 316, no. 1-2, pp. 163–167, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. A. M. Solares, A. Santana, I. Baladrón et al., “Safety and preliminary efficacy data of a novel Casein Kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies,” BMC Cancer, vol. 9, article 146, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Zanin, M. Sandre, G. Cozza et al., “Chimeric peptides as modulators of CK2-dependent signaling: mechanism of action and off-target effects,” Biochimica et Biophysica Acta, 2015. View at Publisher · View at Google Scholar
  29. G. M. Arunesh, E. Shanthi, M. H. Krishna, J. S. Kumar, and V. N. Viswanadhan, “Small molecule inhibitors of PIM1 kinase: July 2009 to February 2013 patent update,” Expert Opinion on Therapeutic Patents, vol. 24, no. 1, pp. 5–17, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. A. L. Merkel, E. Meggers, and M. Ocker, “PIM1 kinase as a target for cancer therapy,” Expert Opinion on Investigational Drugs, vol. 21, no. 4, pp. 425–436, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Blanco-Aparicio and A. Carnero, “Pim kinases in cancer: diagnostic, prognostic and treatment opportunities,” Biochemical Pharmacology, vol. 85, no. 5, pp. 629–643, 2013. View at Publisher · View at Google Scholar