A Comprehensive Review on Cyclodextrin-Based Carriers for Delivery of Chemotherapeutic Cytotoxic Anticancer Drugs

Table 2

Complexation of various anticancer drugs with cyclodextrin and their derivatives.

Serial number	Drug	Use	Cyclodextrin	Method	Outcome	Reference
1	9-Nitro camptothecin	Pancreatic cancer	HP-β-CD	Colyophilization	Significant improvement in antitumor activity and reduction in toxicity	[45]
2	Methotrexate	Melanoma	β-CD; HP β-CD	Neutralization	Enhancement of aqueous solubility and bioavailability	[46]
3	Lonidamine	Prostate cancer	PM-β-CD	Physical mixture	Enhancement of solubility	[47]
4	Exemestane	Breast cancer	M β-CD	Kneading	Increase in solubility, improvement in bioavailability and dissolution	[48]
5	Vorinostat	Lymphoma	HP-β-CD,; RM β-CD	Freeze-drying	Enhancement of bioavailability	[49]
6	Imatinib	Chronic leukemia	β-CD,; RM β-CD	Freeze-drying	Enhancement of solubility	[50]
7	Doxorubicin	Lymphoma and leukemia	HP β-CD	Freeze-drying	Stability to acid hydrolysis and photodegradation	[51]
8	Cisplatin	testicular, ovarian, and cervical carcinoma	HP-β-CD	Freeze-drying and physical mixture	Increase in solubility, improvement in dissolution rate, and reduction of toxicity	[52]
9	Flutamide	Prostatic carcinoma	β-CD,; HP-β-CD	Lyophilization	Enhancement of solubility and dissolution	[53]
10	Zerumbone	Colon and skin cancer	HP-β-CD	Freeze-drying	Improvement in solubility, stability, and bioavailability	[54]
11	Melphalan	Multiple myeloma and ovarian cancer	HP-β-CD	Freeze-drying	Stability against hydrolysis, solubility enhancement	[55]
12	Oridonin	Esophageal and cardiac cancer	β-CD	Freeze-drying	Enhancement of bioavailability	[56]
13	5-Fluorouracil	Cervical cancer	β-CD,; HP β-CD	Colyophilization	Enhancement of solubility	[57]