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BioMed Research International
Volume 2015, Article ID 237863, 12 pages
http://dx.doi.org/10.1155/2015/237863
Research Article

Integration of DCE-MRI and DW-MRI Quantitative Parameters for Breast Lesion Classification

1Department of Diagnostic Imaging, Radiant and Metabolic Therapy, “Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS”, Via Mariano Semmola, 80131 Naples, Italy
2Department of Electrical Engineering and Information Technologies, University “Federico II” of Naples, Via Claudio 21, 80125 Naples, Italy
3Department of Diagnostic and Laboratory Pathology, “Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS”, Via Mariano Semmola, 80131 Naples, Italy
4Department of Senology, “Istituto Nazionale Tumori Fondazione Giovanni Pascale, IRCCS”, Via Mariano Semmola, 80131 Naples, Italy

Received 25 May 2014; Accepted 15 April 2015

Academic Editor: Vivian Barak

Copyright © 2015 Roberta Fusco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The purpose of our study was to evaluate the diagnostic value of an imaging protocol combining dynamic contrast-enhanced MRI (DCE-MRI) and diffusion-weighted MRI (DW-MRI) in patients with suspicious breast lesions. Materials and Methods. A total of 31 breast lesions (15 malignant and 16 benign proved by histological examination) in 26 female patients were included in this study. For both DCE-MRI and DW-MRI model free and model based parameters were computed pixel by pixel on manually segmented ROIs. Statistical procedures included conventional linear analysis and more advanced techniques for classification of lesions in benign and malignant. Results. Our findings indicated no strong correlation between DCE-MRI and DW-MRI parameters. Results of classification analysis show that combining of DCE parameters or DW-MRI parameter, in comparison of single feature, does not yield a dramatic improvement of sensitivity and specificity of the two techniques alone. The best performance was obtained considering a full combination of all features. Moreover, the classification results combining all features are dominated by DCE-MRI features alone. Conclusion. The combination of DWI and DCE-MRI does not show a potential to dramatically increase the sensitivity and specificity of breast MRI. DCE-MRI alone gave the same performance as in combination with DW-MRI.